COR27_ARATH
ID COR27_ARATH Reviewed; 246 AA.
AC Q8L8T7; F4K352; Q3E7U9; Q9FMM9;
DT 18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Cold-regulated protein 27 {ECO:0000303|PubMed:19566593};
GN Name=COR27 {ECO:0000303|PubMed:19566593};
GN OrderedLocusNames=At5g42900 {ECO:0000312|Araport:AT5G42900};
GN ORFNames=MBD2.9 {ECO:0000312|EMBL:BAB09191.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP INDUCTION BY CUCUMBER MOSAIC VIRUS.
RC STRAIN=cv. C24, and cv. Columbia;
RX PubMed=15111722; DOI=10.1093/pcp/pch057;
RA Ishihara T., Sakurai N., Sekine K.-T., Hase S., Ikegami M., Shibata D.,
RA Takahashi H.;
RT "Comparative analysis of expressed sequence tags in resistant and
RT susceptible ecotypes of Arabidopsis thaliana infected with cucumber mosaic
RT virus.";
RL Plant Cell Physiol. 45:470-480(2004).
RN [8]
RP INDUCTION BY ABSCISIC ACID.
RX PubMed=17304219; DOI=10.1038/sj.emboj.7601575;
RA de Torres-Zabala M., Truman W., Bennett M.H., Lafforgue G., Mansfield J.W.,
RA Rodriguez Egea P., Boegre L., Grant M.;
RT "Pseudomonas syringae pv. tomato hijacks the Arabidopsis abscisic acid
RT signalling pathway to cause disease.";
RL EMBO J. 26:1434-1443(2007).
RN [9]
RP INDUCTION BY COLD.
RX PubMed=19566593; DOI=10.1111/j.1365-313x.2009.03957.x;
RA Mikkelsen M.D., Thomashow M.F.;
RT "A role for circadian evening elements in cold-regulated gene expression in
RT Arabidopsis.";
RL Plant J. 60:328-339(2009).
RN [10]
RP FUNCTION, DISRUPTION PHENOTYPE, REPRESSION BY CCA1, AND INDUCTION BY
RP DARKNESS AND COLD.
RC STRAIN=cv. Columbia;
RX PubMed=27837007; DOI=10.1105/tpc.16.00354;
RA Li X., Ma D., Lu S.X., Hu X., Huang R., Liang T., Xu T., Tobin E.M.,
RA Liu H.;
RT "Blue light- and low temperature-regulated COR27 and COR28 play roles in
RT the Arabidopsis circadian clock.";
RL Plant Cell 28:2755-2769(2016).
RN [11]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY DARKNESS AND COLD, REPRESSION
RP BY CCA1, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=27990760; DOI=10.1111/jipb.12512;
RA Wang P., Cui X., Zhao C., Shi L., Zhang G., Sun F., Cao X., Yuan L.,
RA Xie Q., Xu X.;
RT "COR27 and COR28 encode nighttime repressors integrating Arabidopsis
RT circadian clock and cold response.";
RL J. Integr. Plant Biol. 59:78-85(2017).
CC -!- FUNCTION: Together with COR28, involved in central circadian clock
CC regulation and in flowering promotion, by binding to the chromatin of
CC clock-associated evening genes TOC1, PRR5, ELF4 and cold-responsive
CC genes in order to repress their transcription (PubMed:27837007,
CC PubMed:27990760). Negative regulator of freezing tolerance
CC (PubMed:27837007). {ECO:0000269|PubMed:27837007,
CC ECO:0000269|PubMed:27990760}.
CC -!- INTERACTION:
CC Q8L8T7; O23160: MYB73; NbExp=3; IntAct=EBI-25516197, EBI-25506855;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27990760}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8L8T7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8L8T7-2; Sequence=VSP_060271;
CC -!- INDUCTION: Regulated by the circadian clock at warm growth temperatures
CC as direct targets of CCA1, with highest levels from noon to dusk
CC (PubMed:19566593, PubMed:27837007, PubMed:27990760). Repressed by CCA1
CC at the transcription level via chromatin binding and in a temperature-
CC dependent way (PubMed:27837007, PubMed:19566593, PubMed:27990760). 6
CC hours after inoculation with the yellow strain of cucumber mosaic virus
CC [CMV(Y)], strongly induced in resistant cultivars (cv. C24) but
CC repressed in sensitive cultivars (cv. Columbia) (PubMed:15111722).
CC Strongly induced by abscisic acid (ABA) (PubMed:17304219). Rapidly
CC induced by cold, but in a circadian rythm-dependent manner and
CC regulated by CCA1 (PubMed:19566593, PubMed:27837007). Transcription is
CC repressed by blue and red lights, but induced by darkness; by contrast,
CC present at low levels in darkness but accumulates in blue light (at
CC protein level) due to transcription auto-repression (PubMed:27837007).
CC {ECO:0000269|PubMed:15111722, ECO:0000269|PubMed:17304219,
CC ECO:0000269|PubMed:19566593, ECO:0000269|PubMed:27837007,
CC ECO:0000269|PubMed:27990760}.
CC -!- DISRUPTION PHENOTYPE: Period lengthening of various circadian output
CC rhythms and affected central clock gene expression (PubMed:27837007).
CC Derepressed expression of circadian-regulated and cold-responsive genes
CC (PubMed:27990760). Delayed flowering under long days conditions, and
CC slightly in short days (PubMed:27837007). Increased freezing tolerance
CC (PubMed:27837007). {ECO:0000269|PubMed:27837007,
CC ECO:0000269|PubMed:27990760}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09191.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB008264; BAB09191.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED94882.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94883.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94884.1; -; Genomic_DNA.
DR EMBL; AK118095; BAC42723.1; -; mRNA.
DR EMBL; BT005599; AAO64019.1; -; mRNA.
DR EMBL; AK175580; BAD43343.1; -; mRNA.
DR EMBL; AY088816; AAM67125.1; -; mRNA.
DR RefSeq; NP_001031998.1; NM_001036921.2. [Q8L8T7-2]
DR RefSeq; NP_568615.3; NM_123655.5. [Q8L8T7-1]
DR RefSeq; NP_851121.1; NM_180790.2. [Q8L8T7-1]
DR AlphaFoldDB; Q8L8T7; -.
DR IntAct; Q8L8T7; 1.
DR STRING; 3702.AT5G42900.2; -.
DR PaxDb; Q8L8T7; -.
DR ProteomicsDB; 175586; -. [Q8L8T7-1]
DR ProteomicsDB; 211584; -.
DR EnsemblPlants; AT5G42900.1; AT5G42900.1; AT5G42900. [Q8L8T7-1]
DR EnsemblPlants; AT5G42900.2; AT5G42900.2; AT5G42900. [Q8L8T7-1]
DR EnsemblPlants; AT5G42900.3; AT5G42900.3; AT5G42900. [Q8L8T7-2]
DR GeneID; 834301; -.
DR Gramene; AT5G42900.1; AT5G42900.1; AT5G42900. [Q8L8T7-1]
DR Gramene; AT5G42900.2; AT5G42900.2; AT5G42900. [Q8L8T7-1]
DR Gramene; AT5G42900.3; AT5G42900.3; AT5G42900. [Q8L8T7-2]
DR KEGG; ath:AT5G42900; -.
DR Araport; AT5G42900; -.
DR TAIR; locus:2159976; AT5G42900.
DR eggNOG; ENOG502S18J; Eukaryota.
DR HOGENOM; CLU_075435_2_0_1; -.
DR InParanoid; Q8L8T7; -.
DR OMA; KTHCISS; -.
DR OrthoDB; 1121222at2759; -.
DR PhylomeDB; Q8L8T7; -.
DR PRO; PR:Q8L8T7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8L8T7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0042752; P:regulation of circadian rhythm; IMP:UniProtKB.
DR GO; GO:2000028; P:regulation of photoperiodism, flowering; IMP:UniProtKB.
DR GO; GO:0009737; P:response to abscisic acid; IEP:UniProtKB.
DR GO; GO:0009646; P:response to absence of light; IEP:UniProtKB.
DR GO; GO:0009637; P:response to blue light; IEP:UniProtKB.
DR GO; GO:0009409; P:response to cold; IMP:TAIR.
DR GO; GO:0010114; P:response to red light; IEP:UniProtKB.
DR GO; GO:0009615; P:response to virus; IEP:UniProtKB.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR InterPro; IPR044678; COR27/28.
DR PANTHER; PTHR33676; PTHR33676; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Biological rhythms; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..246
FT /note="Cold-regulated protein 27"
FT /id="PRO_0000447852"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 193
FT /note="Missing (in isoform 2)"
FT /id="VSP_060271"
SQ SEQUENCE 246 AA; 27347 MW; B3446513965597DC CRC64;
MVGDYRGRFS SRRFSDDSDD SSDDASSVEG ETTSSMYSAG KEYMETEWTN EKHSLYLKSM
EASFVDQLYN SLGALGKNEN VSESTRFGSG RKPSQEQFKV LHDGFWQKIN VKQPEHRING
RHGGNSHEFL RSPWIKHYKP LVKTQIPVTD EPENQVVSSS NGKKGICSSG SASSLKQLSS
HSRDHDQISV GEAEVSDQNF VNEGIKGENG SSKKMKTVMM SESSSTDQVV PLNKLLQHDV
NLKSVS
