COR28_ARATH
ID COR28_ARATH Reviewed; 218 AA.
AC Q8L983; O81766;
DT 18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Cold-regulated protein 28 {ECO:0000303|PubMed:27837007};
GN Name=COR28 {ECO:0000303|PubMed:27837007};
GN OrderedLocusNames=At4g33980 {ECO:0000312|Araport:AT4G33980};
GN ORFNames=F17I5.170 {ECO:0000312|EMBL:CAA19880.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INDUCTION BY COLD.
RX PubMed=12172015; DOI=10.1105/tpc.003483;
RA Fowler S., Thomashow M.F.;
RT "Arabidopsis transcriptome profiling indicates that multiple regulatory
RT pathways are activated during cold acclimation in addition to the CBF cold
RT response pathway.";
RL Plant Cell 14:1675-1690(2002).
RN [6]
RP INDUCTION BY COLD.
RX PubMed=16121258; DOI=10.1371/journal.pgen.0010026;
RA Hannah M.A., Heyer A.G., Hincha D.K.;
RT "A global survey of gene regulation during cold acclimation in Arabidopsis
RT thaliana.";
RL PLoS Genet. 1:E26-E26(2005).
RN [7]
RP INDUCTION BY ABSCISIC ACID.
RX PubMed=17304219; DOI=10.1038/sj.emboj.7601575;
RA de Torres-Zabala M., Truman W., Bennett M.H., Lafforgue G., Mansfield J.W.,
RA Rodriguez Egea P., Boegre L., Grant M.;
RT "Pseudomonas syringae pv. tomato hijacks the Arabidopsis abscisic acid
RT signalling pathway to cause disease.";
RL EMBO J. 26:1434-1443(2007).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, REPRESSION BY CCA1, AND INDUCTION BY
RP DARKNESS AND COLD.
RC STRAIN=cv. Columbia;
RX PubMed=27837007; DOI=10.1105/tpc.16.00354;
RA Li X., Ma D., Lu S.X., Hu X., Huang R., Liang T., Xu T., Tobin E.M.,
RA Liu H.;
RT "Blue light- and low temperature-regulated COR27 and COR28 play roles in
RT the Arabidopsis circadian clock.";
RL Plant Cell 28:2755-2769(2016).
RN [9]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY DARKNESS AND COLD, REPRESSION
RP BY CCA1, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=27990760; DOI=10.1111/jipb.12512;
RA Wang P., Cui X., Zhao C., Shi L., Zhang G., Sun F., Cao X., Yuan L.,
RA Xie Q., Xu X.;
RT "COR27 and COR28 encode nighttime repressors integrating Arabidopsis
RT circadian clock and cold response.";
RL J. Integr. Plant Biol. 59:78-85(2017).
CC -!- FUNCTION: Together with COR27, involved in central circadian clock
CC regulation and in flowering promotion, by binding to the chromatin of
CC clock-associated evening genes TOC1, PRR5, ELF4 and cold-responsive
CC genes in order to repress their transcription (PubMed:27837007,
CC PubMed:27990760). Negative regulator of freezing tolerance
CC (PubMed:27837007). {ECO:0000269|PubMed:27837007,
CC ECO:0000269|PubMed:27990760}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27990760}.
CC -!- INDUCTION: Regulated by the circadian clock at warm growth temperatures
CC as direct targets of CCA1, with highest levels from noon to dusk
CC (PubMed:27837007, PubMed:27990760). Repressed by CCA1 at the
CC transcription level via chromatin binding and in a temperature-
CC dependent way (PubMed:27837007, PubMed:27990760). Induced by cold
CC (PubMed:12172015, PubMed:16121258, PubMed:27837007). Induced by
CC abscisic acid (ABA) (PubMed:17304219). Transcription is repressed by
CC blue and red lights, but induced by darkness; by contrast, present at
CC low levels in darkness but accumulates in blue light (at protein level)
CC due to transcription auto-repression (PubMed:27837007).
CC {ECO:0000269|PubMed:12172015, ECO:0000269|PubMed:16121258,
CC ECO:0000269|PubMed:17304219, ECO:0000269|PubMed:27837007,
CC ECO:0000269|PubMed:27990760}.
CC -!- DISRUPTION PHENOTYPE: Period lengthening of various circadian output
CC rhythms and affected central clock gene expression (PubMed:27837007).
CC Derepressed expression of circadian-regulated and cold-responsive genes
CC (PubMed:27990760). Delayed flowering under long days conditions, and
CC slightly in short days (PubMed:27837007). Increased freezing tolerance
CC (PubMed:27837007). {ECO:0000269|PubMed:27837007,
CC ECO:0000269|PubMed:27990760}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA19880.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80115.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL031032; CAA19880.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161584; CAB80115.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86303.1; -; Genomic_DNA.
DR EMBL; BT024609; ABD43007.1; -; mRNA.
DR EMBL; AY088585; AAM66115.1; -; mRNA.
DR PIR; T05226; T05226.
DR RefSeq; NP_567946.1; NM_119559.3.
DR AlphaFoldDB; Q8L983; -.
DR STRING; 3702.AT4G33980.2; -.
DR ProteomicsDB; 185131; -.
DR EnsemblPlants; AT4G33980.1; AT4G33980.1; AT4G33980.
DR GeneID; 829544; -.
DR Gramene; AT4G33980.1; AT4G33980.1; AT4G33980.
DR KEGG; ath:AT4G33980; -.
DR Araport; AT4G33980; -.
DR OMA; DREANND; -.
DR PhylomeDB; Q8L983; -.
DR PRO; PR:Q8L983; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8L983; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0042752; P:regulation of circadian rhythm; IMP:UniProtKB.
DR GO; GO:2000028; P:regulation of photoperiodism, flowering; IMP:UniProtKB.
DR GO; GO:0009737; P:response to abscisic acid; IEP:UniProtKB.
DR GO; GO:0009646; P:response to absence of light; IEP:UniProtKB.
DR GO; GO:0009637; P:response to blue light; IEP:UniProtKB.
DR GO; GO:0009409; P:response to cold; IMP:UniProtKB.
DR GO; GO:0010114; P:response to red light; IEP:UniProtKB.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR InterPro; IPR044678; COR27/28.
DR PANTHER; PTHR33676; PTHR33676; 1.
PE 1: Evidence at protein level;
KW Biological rhythms; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..218
FT /note="Cold-regulated protein 28"
FT /id="PRO_0000447853"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 218 AA; 24606 MW; 1D195B021FEA3191 CRC64;
MENDCTVNIV SLEKDRDVSE ASAESQSEST LSNSLDSGVT AETSRSDADS KLDECTAWTN
EKHNSYLDYL ESSFVRQLYS LLGGGTQRLS RTRDVQSNSH KSADQFTVLQ NGCWQKVNFG
KKQSCLETSS EFRFHRNSLR NKPENSNGNY TMGTTVQGDV LCHDETKHSE ASGQNFREEE
EEEEKGEVSK KREREANNDD SSLKEDQVVP VRMVKPRT
