ID   COR2A_BOVIN             Reviewed;         525 AA.
AC   Q32LP9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Coronin-2A;
GN   Name=CORO2A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Binds actin. Component of the N-Cor repressor complex, at
CC       least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
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DR   EMBL; BC109477; AAI09478.1; -; mRNA.
DR   RefSeq; NP_001033309.1; NM_001038220.1.
DR   AlphaFoldDB; Q32LP9; -.
DR   SMR; Q32LP9; -.
DR   STRING; 9913.ENSBTAP00000016014; -.
DR   PaxDb; Q32LP9; -.
DR   PRIDE; Q32LP9; -.
DR   Ensembl; ENSBTAT00000016014; ENSBTAP00000016014; ENSBTAG00000007659.
DR   GeneID; 617620; -.
DR   KEGG; bta:617620; -.
DR   CTD; 7464; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007659; -.
DR   VGNC; VGNC:27623; CORO2A.
DR   eggNOG; KOG0303; Eukaryota.
DR   GeneTree; ENSGT00940000155598; -.
DR   HOGENOM; CLU_026859_4_0_1; -.
DR   InParanoid; Q32LP9; -.
DR   OMA; PRWAVEH; -.
DR   OrthoDB; 552726at2759; -.
DR   TreeFam; TF314280; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000007659; Expressed in jejunum and 101 other tissues.
DR   GO; GO:0017053; C:transcription repressor complex; IEA:InterPro.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR027335; CORO2A.
DR   InterPro; IPR015505; Coronin.
DR   InterPro; IPR015048; DUF1899.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10856; PTHR10856; 1.
DR   PANTHER; PTHR10856:SF2; PTHR10856:SF2; 1.
DR   Pfam; PF08953; DUF1899; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01166; DUF1899; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Coiled coil; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..525
FT                   /note="Coronin-2A"
FT                   /id="PRO_0000278202"
FT   REPEAT          80..120
FT                   /note="WD 1"
FT   REPEAT          130..170
FT                   /note="WD 2"
FT   REPEAT          178..217
FT                   /note="WD 3"
FT   REPEAT          220..263
FT                   /note="WD 4"
FT   REPEAT          269..308
FT                   /note="WD 5"
FT   COILED          485..524
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   525 AA;  59845 MW;  8FC4B2CB9EFE7CEA CRC64;
     MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITHSVQDNHF CAVNPHFIAV VTECTGGGAF
     LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFNDFEIAS CSEDATIKIW DIPKQLLTKN
     LTAFRKELVG HARKVGLVEW HPTAANILFS SGYDYKVMVW NLDSKESVIM SPVKTINCHQ
     DVILSMSFNT NGSLLATACK DRKIRVLDPR AGTVLQEANY KGHRANKVLF LGNLKKLLST
     GTSRWNNRQM ALWDQDDLSV PVTEVDLDGS SGVLFPFYDA DTNMLYVVGK GDRNIHYYEI
     SANKPHLNYL MEYHSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI EPVSMIVPRR
     SESYQEDIYP PTASAQPSLT AQEWLSGMNK EPVLMSLRPG AEPLSPQPLP SERTLSMPTA
     PTSPHLFNQT ESLVAEDGRR PFSLLEEKAP RWAAEHRQEE KKTWLSDGFD IFECPPPKTE
     NELLQMFYRQ QDEIRRLREL VTQREVQAKQ LELEIRNLRM NSPRL