COR2A_HUMAN
ID COR2A_HUMAN Reviewed; 525 AA.
AC Q92828; Q5TBR5; Q92829; Q9BWS5;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 12-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Coronin-2A;
DE AltName: Full=IR10;
DE AltName: Full=WD repeat-containing protein 2;
GN Name=CORO2A; Synonyms=IR10, WDR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epidermis;
RX PubMed=8985118; DOI=10.1089/dna.1996.15.1049;
RA Zaphiropoulos P.G., Toftgard R.;
RT "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3
RT chromosomal region.";
RL DNA Cell Biol. 15:1049-1056(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP COMPONENT OF THE N-COR COMPLEX WITH TBL1R; TBL1X AND HDAC3.
RX PubMed=12628926; DOI=10.1093/emboj/cdg120;
RA Yoon H.-G., Chan D.W., Huang Z.-Q., Li J., Fondell J.D., Qin J., Wong J.;
RT "Purification and functional characterization of the human N-CoR complex:
RT the roles of HDAC3, TBL1 and TBLR1.";
RL EMBO J. 22:1336-1346(2003).
CC -!- SUBUNIT: Binds actin (By similarity). Component of the N-Cor repressor
CC complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A
CC and GPS2. {ECO:0000250}.
CC -!- INTERACTION:
CC Q92828; Q16595: FXN; NbExp=3; IntAct=EBI-2835660, EBI-949340;
CC Q92828; Q99732: LITAF; NbExp=3; IntAct=EBI-2835660, EBI-725647;
CC Q92828; P55055: NR1H2; NbExp=4; IntAct=EBI-2835660, EBI-745354;
CC -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
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DR EMBL; U57057; AAB47807.1; -; mRNA.
DR EMBL; U57058; AAB47808.1; -; mRNA.
DR EMBL; AL137073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471105; EAW58879.1; -; Genomic_DNA.
DR EMBL; BC000010; AAH00010.1; -; mRNA.
DR EMBL; BC011690; AAH11690.1; -; mRNA.
DR CCDS; CCDS6735.1; -.
DR RefSeq; NP_003380.3; NM_003389.3.
DR RefSeq; NP_438171.1; NM_052820.3.
DR RefSeq; XP_011517288.1; XM_011518986.2.
DR AlphaFoldDB; Q92828; -.
DR SMR; Q92828; -.
DR BioGRID; 113302; 61.
DR CORUM; Q92828; -.
DR DIP; DIP-59202N; -.
DR IntAct; Q92828; 47.
DR MINT; Q92828; -.
DR STRING; 9606.ENSP00000343746; -.
DR GlyGen; Q92828; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q92828; -.
DR PhosphoSitePlus; Q92828; -.
DR BioMuta; CORO2A; -.
DR DMDM; 28381354; -.
DR EPD; Q92828; -.
DR jPOST; Q92828; -.
DR MassIVE; Q92828; -.
DR MaxQB; Q92828; -.
DR PaxDb; Q92828; -.
DR PeptideAtlas; Q92828; -.
DR PRIDE; Q92828; -.
DR ProteomicsDB; 75505; -.
DR Antibodypedia; 48737; 97 antibodies from 20 providers.
DR DNASU; 7464; -.
DR Ensembl; ENST00000343933.9; ENSP00000343746.5; ENSG00000106789.13.
DR Ensembl; ENST00000375077.5; ENSP00000364218.4; ENSG00000106789.13.
DR GeneID; 7464; -.
DR KEGG; hsa:7464; -.
DR MANE-Select; ENST00000375077.5; ENSP00000364218.4; NM_052820.4; NP_438171.1.
DR UCSC; uc004ayl.4; human.
DR CTD; 7464; -.
DR DisGeNET; 7464; -.
DR GeneCards; CORO2A; -.
DR HGNC; HGNC:2255; CORO2A.
DR HPA; ENSG00000106789; Tissue enhanced (intestine).
DR MIM; 602159; gene.
DR neXtProt; NX_Q92828; -.
DR OpenTargets; ENSG00000106789; -.
DR PharmGKB; PA26771; -.
DR VEuPathDB; HostDB:ENSG00000106789; -.
DR eggNOG; KOG0303; Eukaryota.
DR GeneTree; ENSGT00940000155598; -.
DR HOGENOM; CLU_026859_4_0_1; -.
DR InParanoid; Q92828; -.
DR OMA; GIXPVLV; -.
DR OrthoDB; 552726at2759; -.
DR PhylomeDB; Q92828; -.
DR TreeFam; TF314280; -.
DR PathwayCommons; Q92828; -.
DR SignaLink; Q92828; -.
DR BioGRID-ORCS; 7464; 9 hits in 1079 CRISPR screens.
DR ChiTaRS; CORO2A; human.
DR GeneWiki; CORO2A; -.
DR GenomeRNAi; 7464; -.
DR Pharos; Q92828; Tbio.
DR PRO; PR:Q92828; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q92828; protein.
DR Bgee; ENSG00000106789; Expressed in jejunal mucosa and 157 other tissues.
DR ExpressionAtlas; Q92828; baseline and differential.
DR Genevisible; Q92828; HS.
DR GO; GO:0017053; C:transcription repressor complex; IDA:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; TAS:ProtInc.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR027335; CORO2A.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR PANTHER; PTHR10856:SF2; PTHR10856:SF2; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Coiled coil; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..525
FT /note="Coronin-2A"
FT /id="PRO_0000050928"
FT REPEAT 24..71
FT /note="WD 1"
FT REPEAT 72..122
FT /note="WD 2"
FT REPEAT 123..170
FT /note="WD 3"
FT REPEAT 171..214
FT /note="WD 4"
FT REPEAT 215..259
FT /note="WD 5"
FT REPEAT 260..305
FT /note="WD 6"
FT REPEAT 306..342
FT /note="WD 7"
FT COILED 485..524
FT /evidence="ECO:0000255"
FT VARIANT 296
FT /note="R -> H (in dbSNP:rs2231666)"
FT /id="VAR_053390"
FT VARIANT 495
FT /note="R -> L (in dbSNP:rs35787916)"
FT /id="VAR_053391"
FT CONFLICT 59
FT /note="A -> G (in Ref. 1; AAB47807)"
FT /evidence="ECO:0000305"
FT CONFLICT 88
FT /note="V -> A (in Ref. 1; AAB47808)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="R -> G (in Ref. 1; AAB47807)"
FT /evidence="ECO:0000305"
FT CONFLICT 373
FT /note="A -> G (in Ref. 1; AAB47807)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 525 AA; 59763 MW; 8546E1C5A78CB1FA CRC64;
MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV VTECAGGGAF
LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFDDFEIAS CSEDATIKIW SIPKQLLTRN
LTAYRKELVG HARRVGLVEW HPTAANILFS AGYDYKVMIW NLDTKESVIT SPMSTISCHQ
DVILSMSFNT NGSLLATTCK DRKIRVIDPR AGTVLQEASY KGHRASKVLF LGNLKKLMST
GTSRWNNRQV ALWDQDNLSV PLMEEDLDGS SGVLFPFYDA DTSMLYVVGK GDGNIRYYEV
SADKPHLSYL TEYRSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI EPISMIVPRR
SESYQEDIYP PTAGAQPSLT AQEWLSGMNR DPILVSLRPG SELLRPHPLP AERPIFNSMA
PASPRLLNQT EKLAAEDGWR SSSLLEEKMP RWAAEHRLEE KKTWLTNGFD VFECPPPKTE
NELLQMFYRQ QEEIRRLREL LTQREVQAKQ LELEIKNLRM GSEQL
