COR2A_MOUSE
ID COR2A_MOUSE Reviewed; 524 AA.
AC Q8C0P5; Q3U6H8; Q8BW42;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Coronin-2A;
GN Name=Coro2a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Ovary, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBUNIT: Binds actin. Component of the N-Cor repressor complex, at
CC least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
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DR EMBL; AK030097; BAC26782.1; -; mRNA.
DR EMBL; AK054394; BAC35761.2; -; mRNA.
DR EMBL; AK152490; BAE31261.1; -; mRNA.
DR EMBL; AK153134; BAE31746.1; -; mRNA.
DR CCDS; CCDS18154.1; -.
DR RefSeq; NP_001158276.1; NM_001164804.1.
DR RefSeq; NP_849224.2; NM_178893.4.
DR AlphaFoldDB; Q8C0P5; -.
DR SMR; Q8C0P5; -.
DR BioGRID; 223484; 6.
DR DIP; DIP-59203N; -.
DR IntAct; Q8C0P5; 1.
DR STRING; 10090.ENSMUSP00000103385; -.
DR iPTMnet; Q8C0P5; -.
DR PhosphoSitePlus; Q8C0P5; -.
DR EPD; Q8C0P5; -.
DR MaxQB; Q8C0P5; -.
DR PaxDb; Q8C0P5; -.
DR PRIDE; Q8C0P5; -.
DR ProteomicsDB; 285252; -.
DR Antibodypedia; 48737; 97 antibodies from 20 providers.
DR DNASU; 107684; -.
DR Ensembl; ENSMUST00000030021; ENSMUSP00000030021; ENSMUSG00000028337.
DR Ensembl; ENSMUST00000107756; ENSMUSP00000103385; ENSMUSG00000028337.
DR GeneID; 107684; -.
DR KEGG; mmu:107684; -.
DR UCSC; uc008sua.2; mouse.
DR CTD; 7464; -.
DR MGI; MGI:1345966; Coro2a.
DR VEuPathDB; HostDB:ENSMUSG00000028337; -.
DR eggNOG; KOG0303; Eukaryota.
DR GeneTree; ENSGT00940000155598; -.
DR HOGENOM; CLU_026859_4_0_1; -.
DR InParanoid; Q8C0P5; -.
DR OMA; PRWAVEH; -.
DR OrthoDB; 552726at2759; -.
DR PhylomeDB; Q8C0P5; -.
DR TreeFam; TF314280; -.
DR BioGRID-ORCS; 107684; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Coro2a; mouse.
DR PRO; PR:Q8C0P5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C0P5; protein.
DR Bgee; ENSMUSG00000028337; Expressed in seminal vesicle and 226 other tissues.
DR ExpressionAtlas; Q8C0P5; baseline and differential.
DR Genevisible; Q8C0P5; MM.
DR GO; GO:0005903; C:brush border; IDA:UniProtKB.
DR GO; GO:0017053; C:transcription repressor complex; ISO:MGI.
DR GO; GO:0003779; F:actin binding; ISA:MGI.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR027335; CORO2A.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR PANTHER; PTHR10856:SF2; PTHR10856:SF2; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Coiled coil; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..524
FT /note="Coronin-2A"
FT /id="PRO_0000050929"
FT REPEAT 80..120
FT /note="WD 1"
FT REPEAT 130..170
FT /note="WD 2"
FT REPEAT 178..217
FT /note="WD 3"
FT REPEAT 220..263
FT /note="WD 4"
FT REPEAT 269..308
FT /note="WD 5"
FT REGION 403..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 484..523
FT /evidence="ECO:0000255"
FT COMPBIAS 410..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 9
FT /note="S -> R (in Ref. 1; BAC35761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 524 AA; 59573 MW; 21F73CFB3B27A5E7 CRC64;
MSWHPQYRSS KFRHVYGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV VTECAGGGAF
LVIPLHQTGK LDPHYPKVCG HRGNVLDIKW NPFNDFEIAS CSEDATIKIW NIPKQLLTRN
LTTYRKELIG HARRVGLVEW HPTTANILFS AGYDYKVMVW NLDTKDSVIA GPVKTINCHQ
DVILSMSFNT NGSLLATTCK DRKIRIVDPR LGIVLQEASY KGHRANKVLF LGSLKKLLST
GTSRWNNRQM ALWDQENLSV PLTEEDLDGS SGVLFPFFDS DTSMLYIVGK GDGNIRYYEV
SMEKPHLTYL TEYRSYNPQK GIGIMPKRGL DVSSCEIFRF YKLITTKSLI EPVSMIVPRR
SESYQEDIYP PTAAAQPSLT AHEWLSGMNR GPIMMSLRPG SELLDSQTLP PERPLSNSMV
QVSPQPLEPM KQPAEDGDQA PFSLLEEKLA KWTAEHHLGE KSCLTNGFDV FECSPPKTEN
ELLQMFYRQQ EEIRRLRELL IQREVQTKQL ELEIKNLRMA LGQL
