COR2B_MOUSE
ID COR2B_MOUSE Reviewed; 480 AA.
AC Q8BH44; Q6P5U9;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Coronin-2B;
GN Name=Coro2b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in the reorganization of neuronal actin
CC structure. {ECO:0000250}.
CC -!- SUBUNIT: Binds to F-actin and to vinculin. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH62649.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC33080.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC39865.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK047527; BAC33080.1; ALT_INIT; mRNA.
DR EMBL; AK087414; BAC39865.1; ALT_INIT; mRNA.
DR EMBL; BC062649; AAH62649.1; ALT_INIT; mRNA.
DR CCDS; CCDS23264.2; -.
DR RefSeq; NP_780693.2; NM_175484.3.
DR RefSeq; XP_006511157.2; XM_006511094.3.
DR RefSeq; XP_006511160.1; XM_006511097.3.
DR RefSeq; XP_006511161.1; XM_006511098.3.
DR RefSeq; XP_006511162.1; XM_006511099.3.
DR RefSeq; XP_006511163.1; XM_006511100.2.
DR AlphaFoldDB; Q8BH44; -.
DR SMR; Q8BH44; -.
DR BioGRID; 231659; 5.
DR IntAct; Q8BH44; 1.
DR MINT; Q8BH44; -.
DR STRING; 10090.ENSMUSP00000041826; -.
DR iPTMnet; Q8BH44; -.
DR PhosphoSitePlus; Q8BH44; -.
DR SwissPalm; Q8BH44; -.
DR MaxQB; Q8BH44; -.
DR PaxDb; Q8BH44; -.
DR PeptideAtlas; Q8BH44; -.
DR PRIDE; Q8BH44; -.
DR ProteomicsDB; 285265; -.
DR Antibodypedia; 2828; 170 antibodies from 24 providers.
DR DNASU; 235431; -.
DR Ensembl; ENSMUST00000048043; ENSMUSP00000041826; ENSMUSG00000041729.
DR GeneID; 235431; -.
DR KEGG; mmu:235431; -.
DR UCSC; uc009qaj.1; mouse.
DR CTD; 10391; -.
DR MGI; MGI:2444283; Coro2b.
DR VEuPathDB; HostDB:ENSMUSG00000041729; -.
DR eggNOG; KOG0303; Eukaryota.
DR GeneTree; ENSGT00940000158689; -.
DR HOGENOM; CLU_026859_4_0_1; -.
DR InParanoid; Q8BH44; -.
DR OMA; KQSWFRG; -.
DR OrthoDB; 552726at2759; -.
DR PhylomeDB; Q8BH44; -.
DR TreeFam; TF314280; -.
DR BioGRID-ORCS; 235431; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Coro2b; mouse.
DR PRO; PR:Q8BH44; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BH44; protein.
DR Bgee; ENSMUSG00000041729; Expressed in retinal neural layer and 200 other tissues.
DR ExpressionAtlas; Q8BH44; baseline and differential.
DR Genevisible; Q8BH44; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IDA:MGI.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0001725; C:stress fiber; ISO:MGI.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:1990147; F:talin binding; ISO:MGI.
DR GO; GO:0017166; F:vinculin binding; ISO:MGI.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0048041; P:focal adhesion assembly; IMP:MGI.
DR GO; GO:0010812; P:negative regulation of cell-substrate adhesion; ISO:MGI.
DR GO; GO:1904950; P:negative regulation of establishment of protein localization; ISO:MGI.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IMP:MGI.
DR GO; GO:1904951; P:positive regulation of establishment of protein localization; ISO:MGI.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; ISO:MGI.
DR GO; GO:0080135; P:regulation of cellular response to stress; ISO:MGI.
DR GO; GO:0003093; P:regulation of glomerular filtration; IMP:MGI.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR027339; CORO2B.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR PANTHER; PTHR10856:SF17; PTHR10856:SF17; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..480
FT /note="Coronin-2B"
FT /id="PRO_0000050931"
FT REPEAT 85..125
FT /note="WD 1"
FT REPEAT 135..177
FT /note="WD 2"
FT REPEAT 179..217
FT /note="WD 3"
FT REPEAT 220..263
FT /note="WD 4"
FT REPEAT 265..308
FT /note="WD 5"
FT COILED 436..479
FT /evidence="ECO:0000255"
FT CONFLICT 203
FT /note="K -> N (in Ref. 2; AAH62649)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 480 AA; 54936 MW; DD3D9E9C12EF41FE CRC64;
MTVTKMSWRP QYRSSKFRNV YGKAANREHC FDGIPITKNV HDNHFCAVNA RFLAIVTESA
GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID NIIASCSEDT SVRIWEIPDG
GLKRNMTEAL LELHGHSRRV GLVEWHPTTN NILFSAGYDY KVLIWNLDIG EPVKMIDCHT
DVILCMSFNT DGSLLTTTCK DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT
GVSRWNTRQI ALWDQEDLSM PMIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI EPISMIVPRR
SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG YKKSSKVVFK APIREKKSVV
VNGIDLLENV PPRTENELLR MFFRQQDEIR RLKEELAQKD IRLRQLQLEL KNLRNNPKNC
