ID   COR2B_XENTR             Reviewed;         480 AA.
AC   A8WGE3; Q28E22;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Coronin-2B;
GN   Name=coro2b; ORFNames=TEgg100f23.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the reorganization of neuronal actin
CC       structure. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A8WGE3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A8WGE3-2; Sequence=VSP_037707;
CC   -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
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DR   EMBL; CR848488; CAJ81788.1; -; mRNA.
DR   EMBL; BC154677; AAI54678.1; -; mRNA.
DR   RefSeq; NP_001016965.1; NM_001016965.2. [A8WGE3-2]
DR   RefSeq; XP_012814524.1; XM_012959070.2. [A8WGE3-1]
DR   RefSeq; XP_012814525.1; XM_012959071.2. [A8WGE3-2]
DR   RefSeq; XP_012814526.1; XM_012959072.2. [A8WGE3-2]
DR   AlphaFoldDB; A8WGE3; -.
DR   SMR; A8WGE3; -.
DR   STRING; 8364.ENSXETP00000017076; -.
DR   PaxDb; A8WGE3; -.
DR   GeneID; 549719; -.
DR   KEGG; xtr:549719; -.
DR   CTD; 10391; -.
DR   Xenbase; XB-GENE-1014762; coro2b.
DR   eggNOG; KOG0303; Eukaryota.
DR   HOGENOM; CLU_026859_4_0_1; -.
DR   InParanoid; A8WGE3; -.
DR   OrthoDB; 552726at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025308; Expressed in brain and 11 other tissues.
DR   ExpressionAtlas; A8WGE3; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR027339; CORO2B.
DR   InterPro; IPR015505; Coronin.
DR   InterPro; IPR015048; DUF1899.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10856; PTHR10856; 1.
DR   PANTHER; PTHR10856:SF17; PTHR10856:SF17; 1.
DR   Pfam; PF08953; DUF1899; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01166; DUF1899; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..480
FT                   /note="Coronin-2B"
FT                   /id="PRO_0000379779"
FT   REPEAT          85..125
FT                   /note="WD 1"
FT   REPEAT          135..177
FT                   /note="WD 2"
FT   REPEAT          179..217
FT                   /note="WD 3"
FT   REPEAT          220..263
FT                   /note="WD 4"
FT   REPEAT          265..308
FT                   /note="WD 5"
FT   COILED          436..475
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..6
FT                   /note="MTVTKM -> M (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_037707"
SQ   SEQUENCE   480 AA;  55109 MW;  DF1A02459319873C CRC64;
     MTVTKMSWRP QYRCSKFRNV YGKVASRENC YDCIPITKNV HDNHFCAVNP KFLAIVTETA
     GGGSFLVIPL QQTGRIEPNY PKVCGHQGTV LDIKWNPFIE NIIASCSEDT SVRIWEIPDG
     GLKRNMSEAV LELYGHSRRV GLIEWHPTAI NILFSAGYDY KILIWNLDIG EAVKMIDCHR
     DVILCMSFNT DGSLLATTCK DKKLRVLEPR SGRVLQETAC KTHKVTRVVF LGDMKRLFTT
     GVSKWNTRQM ALWDQEDLSM PVTEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
     TAEKPYLTYL MEFRSPAPQK GLGVMPKHGL DVSACEIFRF YKLITLKNQI EPISMIVPRR
     SENYQEDIYP MTSGTEPALR PEEWLRGVNK GPVLMSLKEG YRKENKAIFI APVKEKKSLV
     VNGIDLLENV PPRTENELLR MFFRQQEEIR RLKEQLSQRD LLVRQLELEL KNLRNSPKDS