CORA_HELPY
ID CORA_HELPY Reviewed; 318 AA.
AC O25901;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Magnesium transport protein CorA;
GN Name=corA; OrderedLocusNames=HP_1344;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=12065537; DOI=10.1128/iai.70.7.3930-3934.2002;
RA Pfeiffer J., Guhl J., Waidner B., Kist M., Bereswill S.;
RT "Magnesium uptake by CorA is essential for viability of the gastric
RT pathogen Helicobacter pylori.";
RL Infect. Immun. 70:3930-3934(2002).
CC -!- FUNCTION: Mediates influx of magnesium ions. Can also mediate cobalt
CC and nickel uptake. Plays a key role in the adaptation to the low
CC magnesium conditions predominant in the gastric environment
CC (PubMed:12065537). Alternates between open and closed states. Activated
CC by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+)
CC levels are high (By similarity). {ECO:0000250|UniProtKB:Q9WZ31,
CC ECO:0000269|PubMed:12065537}.
CC -!- SUBUNIT: Homopentamer. In the absence of Mg(2+), interactions between
CC subunits are weakened, and dimers, trimers and tetramers can be
CC observed in vitro (By similarity). {ECO:0000250|UniProtKB:Q9WZ31}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000305|PubMed:12065537}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9WZ31}.
CC -!- DOMAIN: The central ion permeation pathway is formed by the first
CC transmembrane domain from each of the five subunits. Mg(2+) binding
CC strengthens interactions between subunits and leads to the formation of
CC a symmetrical homopentamer surrounding a closed ion permeation pathway.
CC Co(2+) binding also induces a conformation change. Low Mg(2+)
CC concentrations trigger both a conformation change within each subunit
CC and a loosening of the interactions between subunits. This results in
CC an open ion conduction pathway. In addition, this results in a less
CC symmetrical shape of the whole complex. {ECO:0000250|UniProtKB:Q9WZ31}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08385.1; -; Genomic_DNA.
DR PIR; H64687; H64687.
DR RefSeq; NP_208136.1; NC_000915.1.
DR RefSeq; WP_000248522.1; NC_018939.1.
DR AlphaFoldDB; O25901; -.
DR SMR; O25901; -.
DR IntAct; O25901; 1.
DR MINT; O25901; -.
DR STRING; 85962.C694_06935; -.
DR PaxDb; O25901; -.
DR PRIDE; O25901; -.
DR EnsemblBacteria; AAD08385; AAD08385; HP_1344.
DR KEGG; hpy:HP_1344; -.
DR PATRIC; fig|85962.47.peg.1439; -.
DR eggNOG; COG0598; Bacteria.
DR OMA; RQNDDMR; -.
DR PhylomeDB; O25901; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IBA:GO_Central.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR004488; Mg/Co-transport_prot_CorA.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; SSF143865; 1.
DR SUPFAM; SSF144083; SSF144083; 1.
DR TIGRFAMs; TIGR00383; corA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cobalt; Ion transport; Magnesium;
KW Membrane; Nickel; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..318
FT /note="Magnesium transport protein CorA"
FT /id="PRO_0000239048"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 279..281
FT /note="Probable selectivity filter"
FT /evidence="ECO:0000250|UniProtKB:Q9WZ31"
FT SITE 255
FT /note="Essential for ion permeation"
FT /evidence="ECO:0000250|UniProtKB:Q9WZ31"
SQ SEQUENCE 318 AA; 37136 MW; 06CC4966F02C0CC5 CRC64;
MVNVFFKQQK FVIKKRFNDF NGFDIEENEV LWFELINPTP NELATLSQEY AIHYNTDHSQ
RVSSVTKYWE DSSSVTINAF FTNQDENETF HTEMATFILS NNILFTIYYG TLEIFDSIQK
KVLASPKKFE DGFDILTKIF EVYFEKGVEC LEWINKQTSL LRKNIIFKET STHDDILVRL
SNLQEFNVTL RDSFFDKRRI ITALLRSNKV DSDTKNNLNI ILTDFSSLVE STTVNLNSLD
NIQNLFASQV NVEQNKIIKL FTVATMAMMP PTLIGTIYGM NFKFMPELEW QYGYLFALIV
MAISTILPVI YFKKKGWL
