CORA_MANSM
ID CORA_MANSM Reviewed; 316 AA.
AC Q65VT3;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Magnesium transport protein CorA;
GN Name=corA; OrderedLocusNames=MS0320;
OS Mannheimia succiniciproducens (strain MBEL55E).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Basfia.
OX NCBI_TaxID=221988;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MBEL55E;
RX PubMed=15378067; DOI=10.1038/nbt1010;
RA Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA Jeong H., Hur C.G., Kim J.J.;
RT "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT succiniciproducens.";
RL Nat. Biotechnol. 22:1275-1281(2004).
CC -!- FUNCTION: Mediates influx of magnesium ions. Can also mediate cobalt
CC and manganese uptake (By similarity). Alternates between open and
CC closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive
CC when cytoplasmic Mg(2+) levels are high (By similarity).
CC {ECO:0000250|UniProtKB:P0ABI4, ECO:0000250|UniProtKB:Q9WZ31}.
CC -!- SUBUNIT: Homopentamer. In the absence of Mg(2+), interactions between
CC subunits are weakened, and dimers, trimers and tetramers can be
CC observed in vitro (By similarity). {ECO:0000250|UniProtKB:Q9WZ31}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0ABI4}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9WZ31}.
CC -!- DOMAIN: The central ion permeation pathway is formed by the first
CC transmembrane domain from each of the five subunits. Mg(2+) binding
CC strengthens interactions between subunits and leads to the formation of
CC a symmetrical homopentamer surrounding a closed ion permeation pathway.
CC Co(2+) binding also induces a conformation change. Low Mg(2+)
CC concentrations trigger both a conformation change within each subunit
CC and a loosening of the interactions between subunits. This results in
CC an open ion conduction pathway. In addition, this results in a less
CC symmetrical shape of the whole complex. {ECO:0000250|UniProtKB:Q9WZ31}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000305}.
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DR EMBL; AE016827; AAU36927.1; -; Genomic_DNA.
DR RefSeq; WP_011199502.1; NC_006300.1.
DR AlphaFoldDB; Q65VT3; -.
DR SMR; Q65VT3; -.
DR STRING; 221988.MS0320; -.
DR EnsemblBacteria; AAU36927; AAU36927; MS0320.
DR KEGG; msu:MS0320; -.
DR eggNOG; COG0598; Bacteria.
DR HOGENOM; CLU_007127_5_0_6; -.
DR OMA; RQNDDMR; -.
DR OrthoDB; 822653at2; -.
DR Proteomes; UP000000607; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR004488; Mg/Co-transport_prot_CorA.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; SSF143865; 1.
DR SUPFAM; SSF144083; SSF144083; 1.
DR TIGRFAMs; TIGR00383; corA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Magnesium; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..316
FT /note="Magnesium transport protein CorA"
FT /id="PRO_0000239098"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 277..279
FT /note="Probable selectivity filter"
FT /evidence="ECO:0000250|UniProtKB:Q9WZ31"
FT SITE 253
FT /note="Essential for ion permeation"
FT /evidence="ECO:0000250|UniProtKB:Q9WZ31"
SQ SEQUENCE 316 AA; 36639 MW; 1F8D9A1B8E80E627 CRC64;
MINAFALENA RLTRLDEDNL STLNKAIWID LVEPTSEERE ILQDGLEQSL ASFLELEDIE
ASARFFEDED GLHLHSFFYC EDEEDYADLA SVAFTIRDGR LFTLRDRDLP AFRLYRMRSR
YQRLDECNAY EVLLDLFETK IEQLADVIET VYSDLERLSR VILDGKQGEA FDDALGTLTE
QEDMSSKVRL CLMDTQRALS FLVRKTRLPA NQLEQAREIL RDIESLQPHN ESLFQKVNFL
MQAAMGYINI EQNRVMKFFS VVSVMFLPAT LVASTYGMNF EFMPELGFKY GYPMAIGLMI
AAGVTPYMYF KRKGWL