ID   CORC_ECOLI              Reviewed;         292 AA.
AC   P0AE78; P77392;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Magnesium and cobalt efflux protein CorC;
GN   Name=corC; Synonyms=ybeX; OrderedLocusNames=b0658, JW0655;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Plays a role in the transport of magnesium and cobalt ions.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; U82598; AAB40860.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73759.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA35309.2; -; Genomic_DNA.
DR   PIR; H64800; H64800.
DR   RefSeq; NP_415191.1; NC_000913.3.
DR   RefSeq; WP_001278605.1; NZ_STEB01000031.1.
DR   PDB; 4HG0; X-ray; 3.10 A; A=1-292.
DR   PDB; 5YZ2; X-ray; 1.75 A; A/B=67-193.
DR   PDBsum; 4HG0; -.
DR   PDBsum; 5YZ2; -.
DR   AlphaFoldDB; P0AE78; -.
DR   SMR; P0AE78; -.
DR   BioGRID; 4260830; 549.
DR   DIP; DIP-35960N; -.
DR   IntAct; P0AE78; 9.
DR   STRING; 511145.b0658; -.
DR   jPOST; P0AE78; -.
DR   PaxDb; P0AE78; -.
DR   PRIDE; P0AE78; -.
DR   EnsemblBacteria; AAC73759; AAC73759; b0658.
DR   EnsemblBacteria; BAA35309; BAA35309; BAA35309.
DR   GeneID; 67416302; -.
DR   GeneID; 946417; -.
DR   KEGG; ecj:JW0655; -.
DR   KEGG; eco:b0658; -.
DR   PATRIC; fig|1411691.4.peg.1610; -.
DR   EchoBASE; EB3418; -.
DR   eggNOG; COG4535; Bacteria.
DR   HOGENOM; CLU_015237_3_0_6; -.
DR   InParanoid; P0AE78; -.
DR   OMA; QMISIKA; -.
DR   PhylomeDB; P0AE78; -.
DR   BioCyc; EcoCyc:G6361-MON; -.
DR   PRO; PR:P0AE78; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   1: Evidence at protein level;
KW   3D-structure; CBS domain; Cobalt; Magnesium; Reference proteome; Repeat;
KW   Transport.
FT   CHAIN           1..292
FT                   /note="Magnesium and cobalt efflux protein CorC"
FT                   /id="PRO_0000088345"
FT   DOMAIN          73..133
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          135..195
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   HELIX           52..66
FT                   /evidence="ECO:0007829|PDB:4HG0"
FT   HELIX           69..72
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   STRAND          73..75
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   HELIX           76..78
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   STRAND          82..86
FT                   /evidence="ECO:0007829|PDB:4HG0"
FT   HELIX           88..98
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   STRAND          101..109
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   STRAND          112..118
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   HELIX           119..126
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   HELIX           135..138
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   STRAND          144..146
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   HELIX           151..161
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   STRAND          164..169
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   STRAND          175..180
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   HELIX           181..192
FT                   /evidence="ECO:0007829|PDB:5YZ2"
FT   STRAND          206..208
FT                   /evidence="ECO:0007829|PDB:4HG0"
FT   STRAND          211..215
FT                   /evidence="ECO:0007829|PDB:4HG0"
FT   HELIX           220..227
FT                   /evidence="ECO:0007829|PDB:4HG0"
FT   HELIX           239..247
FT                   /evidence="ECO:0007829|PDB:4HG0"
FT   STRAND          256..261
FT                   /evidence="ECO:0007829|PDB:4HG0"
FT   STRAND          263..269
FT                   /evidence="ECO:0007829|PDB:4HG0"
FT   STRAND          274..280
FT                   /evidence="ECO:0007829|PDB:4HG0"
SQ   SEQUENCE   292 AA;  33298 MW;  7350B8B475485B32 CRC64;
     MSDDNSHSSD TISNKKGFFS LLLSQLFHGE PKNRDELLAL IRDSGQNDLI DEDTRDMLEG
     VMDIADQRVR DIMIPRSQMI TLKRNQTLDE CLDVIIESAH SRFPVISEDK DHIEGILMAK
     DLLPFMRSDA EAFSMDKVLR QAVVVPESKR VDRMLKEFRS QRYHMAIVID EFGGVSGLVT
     IEDILELIVG EIEDEYDEED DIDFRQLSRH TWTVRALASI EDFNEAFGTH FSDEEVDTIG
     GLVMQAFGHL PARGETIDID GYQFKVAMAD SRRIIQVHVK IPDDSPQPKL DE