CORC_HAEIN
ID CORC_HAEIN Reviewed; 299 AA.
AC Q57368;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Magnesium and cobalt efflux protein CorC;
GN Name=corC; OrderedLocusNames=HI_0301;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Plays a role in the transport of magnesium and cobalt ions.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L42023; AAC21966.1; -; Genomic_DNA.
DR PIR; G64060; G64060.
DR RefSeq; NP_438468.1; NC_000907.1.
DR RefSeq; WP_005694364.1; NC_000907.1.
DR AlphaFoldDB; Q57368; -.
DR SMR; Q57368; -.
DR STRING; 71421.HI_0301; -.
DR EnsemblBacteria; AAC21966; AAC21966; HI_0301.
DR KEGG; hin:HI_0301; -.
DR PATRIC; fig|71421.8.peg.318; -.
DR eggNOG; COG4535; Bacteria.
DR HOGENOM; CLU_015237_3_0_6; -.
DR OMA; QMISIKA; -.
DR PhylomeDB; Q57368; -.
DR BioCyc; HINF71421:G1GJ1-319-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF56176; SSF56176; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain; Cobalt; Magnesium; Reference proteome; Repeat; Transport.
FT CHAIN 1..299
FT /note="Magnesium and cobalt efflux protein CorC"
FT /id="PRO_0000088348"
FT DOMAIN 73..134
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 140..197
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ SEQUENCE 299 AA; 34584 MW; 181F455BF44F0213 CRC64;
MNDEQQNSNQ SENTKKPFFQ SLFGRFFQGE LKNREELVEV IRDSEQNDLI DQNTREMIEG
VMEIAELRVR DIMIPRSQII FIEDQQDLNT CLNTIIESAH SRFPVIADAD DRDNIVGILH
AKDLLKFLRE DAEVFDLSSL LRPVVIVPES KRVDRMLKDF RSERFHMAIV VDEFGAVSGL
VTIEDILEQI VGDIEDEFDE EEIADIRQLS RHTYAVRALT DIDDFNAQFN TDFDDEEVDT
IGGLIMQTFG YLPKRGEEII LKNLQFKVTS ADSRRLIQLR VTVPDEHLAE MNNVDEKSE