ID   CORC_SHIFL              Reviewed;         292 AA.
AC   P0AE81; P77392;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Magnesium and cobalt efflux protein CorC;
GN   Name=corC; OrderedLocusNames=SF0624, S0646;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Plays a role in the transport of magnesium and cobalt ions.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN42261.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP16132.1; -; Genomic_DNA.
DR   RefSeq; NP_706554.1; NC_004337.2.
DR   RefSeq; WP_001278605.1; NZ_WPGW01000002.1.
DR   AlphaFoldDB; P0AE81; -.
DR   SMR; P0AE81; -.
DR   STRING; 198214.SF0624; -.
DR   EnsemblBacteria; AAN42261; AAN42261; SF0624.
DR   EnsemblBacteria; AAP16132; AAP16132; S0646.
DR   GeneID; 1027544; -.
DR   GeneID; 67416302; -.
DR   KEGG; sfl:SF0624; -.
DR   KEGG; sfx:S0646; -.
DR   PATRIC; fig|198214.7.peg.729; -.
DR   HOGENOM; CLU_015237_3_0_6; -.
DR   OMA; QMISIKA; -.
DR   OrthoDB; 1155802at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain; Cobalt; Magnesium; Reference proteome; Repeat; Transport.
FT   CHAIN           1..292
FT                   /note="Magnesium and cobalt efflux protein CorC"
FT                   /id="PRO_0000088352"
FT   DOMAIN          73..133
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          135..195
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   292 AA;  33298 MW;  7350B8B475485B32 CRC64;
     MSDDNSHSSD TISNKKGFFS LLLSQLFHGE PKNRDELLAL IRDSGQNDLI DEDTRDMLEG
     VMDIADQRVR DIMIPRSQMI TLKRNQTLDE CLDVIIESAH SRFPVISEDK DHIEGILMAK
     DLLPFMRSDA EAFSMDKVLR QAVVVPESKR VDRMLKEFRS QRYHMAIVID EFGGVSGLVT
     IEDILELIVG EIEDEYDEED DIDFRQLSRH TWTVRALASI EDFNEAFGTH FSDEEVDTIG
     GLVMQAFGHL PARGETIDID GYQFKVAMAD SRRIIQVHVK IPDDSPQPKL DE