ID   CORC_VIBCH              Reviewed;         291 AA.
AC   Q9KTE3;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Magnesium and cobalt efflux protein CorC;
GN   Name=corC; OrderedLocusNames=VC_0959;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Plays a role in the transport of magnesium and cobalt ions.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE003852; AAF94121.1; -; Genomic_DNA.
DR   PIR; B82261; B82261.
DR   RefSeq; NP_230606.1; NC_002505.1.
DR   RefSeq; WP_001001301.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KTE3; -.
DR   SMR; Q9KTE3; -.
DR   STRING; 243277.VC_0959; -.
DR   DNASU; 2614212; -.
DR   EnsemblBacteria; AAF94121; AAF94121; VC_0959.
DR   GeneID; 57739648; -.
DR   KEGG; vch:VC_0959; -.
DR   PATRIC; fig|243277.26.peg.913; -.
DR   eggNOG; COG4535; Bacteria.
DR   HOGENOM; CLU_015237_3_0_6; -.
DR   OMA; QMISIKA; -.
DR   BioCyc; VCHO:VC0959-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain; Cobalt; Magnesium; Reference proteome; Repeat; Transport.
FT   CHAIN           1..291
FT                   /note="Magnesium and cobalt efflux protein CorC"
FT                   /id="PRO_0000088353"
FT   DOMAIN          71..131
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          136..193
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   291 AA;  32916 MW;  1930D11133B24CE6 CRC64;
     MNEDNSQNSE GPSRKSFFER LSQLFQGEPK DRQELVDVIR DSEVNDLIDH DTRDMLEGVM
     EIAEMRVRDI MIPRSQMVTI DRTHNLDALV AIMTDAQHSR YPVISEDKDH VEGILLAKDL
     LKYLGSNCAP FNIQEVIRPA VVVPESKRVD RLLKEFREER YHMAIVVDEF GGVSGLVTIE
     DILEEIVGDI EDEFDDEEQK DIRQLSKHTF SVKALTTIED FNHTFGTKFS DEEVDTVGGL
     VMTAFGHLPA RGEVVDIAGY NFKVTAADSR RVVALQVTVP DLEALSHVAE E