CORO6_HUMAN
ID CORO6_HUMAN Reviewed; 472 AA.
AC Q6QEF8; B3KU26; Q71MF3; Q8WYH7; Q96K02;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Coronin-6;
DE AltName: Full=Coronin-like protein E;
DE Short=Clipin-E;
GN Name=CORO6; ORFNames=PP1009, PP1782, PP1881;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Shen C., Wang C., Li H., Zhou G., Ke R., Zhong G., Lin L., Yang S.;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 32-472 (ISOFORM 5).
RC TISSUE=Placenta, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6QEF8; Q9UL45: BLOC1S6; NbExp=3; IntAct=EBI-10254194, EBI-465781;
CC Q6QEF8-4; P23560-2: BDNF; NbExp=3; IntAct=EBI-10699285, EBI-12275524;
CC Q6QEF8-4; P02511: CRYAB; NbExp=3; IntAct=EBI-10699285, EBI-739060;
CC Q6QEF8-4; P07900: HSP90AA1; NbExp=3; IntAct=EBI-10699285, EBI-296047;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6QEF8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6QEF8-2; Sequence=VSP_021484;
CC Name=3;
CC IsoId=Q6QEF8-3; Sequence=VSP_021484, VSP_021486;
CC Name=4;
CC IsoId=Q6QEF8-4; Sequence=VSP_021485, VSP_021486;
CC Name=5;
CC IsoId=Q6QEF8-5; Sequence=VSP_039874;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG22467.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=BAG53288.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF193039; AAG22467.1; ALT_SEQ; mRNA.
DR EMBL; AF447884; AAQ04659.1; -; mRNA.
DR EMBL; AF447885; AAQ04660.1; -; mRNA.
DR EMBL; AY545070; AAS48630.1; -; mRNA.
DR EMBL; AK027777; BAB55360.1; -; mRNA.
DR EMBL; AK096431; BAG53288.1; ALT_INIT; mRNA.
DR EMBL; AC104564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC064514; AAH64514.1; -; mRNA.
DR CCDS; CCDS11252.2; -. [Q6QEF8-5]
DR RefSeq; NP_116243.2; NM_032854.3. [Q6QEF8-5]
DR RefSeq; XP_005258104.1; XM_005258047.3. [Q6QEF8-5]
DR RefSeq; XP_005258113.1; XM_005258056.4. [Q6QEF8-4]
DR PDB; 7KYX; X-ray; 1.63 A; A=1-409.
DR PDBsum; 7KYX; -.
DR AlphaFoldDB; Q6QEF8; -.
DR SMR; Q6QEF8; -.
DR BioGRID; 124374; 54.
DR IntAct; Q6QEF8; 21.
DR MINT; Q6QEF8; -.
DR STRING; 9606.ENSP00000344562; -.
DR iPTMnet; Q6QEF8; -.
DR PhosphoSitePlus; Q6QEF8; -.
DR BioMuta; CORO6; -.
DR DMDM; 119369490; -.
DR EPD; Q6QEF8; -.
DR jPOST; Q6QEF8; -.
DR MassIVE; Q6QEF8; -.
DR MaxQB; Q6QEF8; -.
DR PaxDb; Q6QEF8; -.
DR PeptideAtlas; Q6QEF8; -.
DR PRIDE; Q6QEF8; -.
DR ProteomicsDB; 67283; -. [Q6QEF8-1]
DR ProteomicsDB; 67284; -. [Q6QEF8-2]
DR ProteomicsDB; 67285; -. [Q6QEF8-3]
DR ProteomicsDB; 67286; -. [Q6QEF8-4]
DR ProteomicsDB; 67287; -. [Q6QEF8-5]
DR Antibodypedia; 54318; 127 antibodies from 17 providers.
DR DNASU; 84940; -.
DR Ensembl; ENST00000345068.9; ENSP00000344562.5; ENSG00000167549.19. [Q6QEF8-5]
DR Ensembl; ENST00000388767.8; ENSP00000373419.3; ENSG00000167549.19. [Q6QEF8-5]
DR GeneID; 84940; -.
DR KEGG; hsa:84940; -.
DR MANE-Select; ENST00000388767.8; ENSP00000373419.3; NM_032854.4; NP_116243.2. [Q6QEF8-5]
DR UCSC; uc002hel.2; human. [Q6QEF8-1]
DR CTD; 84940; -.
DR DisGeNET; 84940; -.
DR GeneCards; CORO6; -.
DR HGNC; HGNC:21356; CORO6.
DR HPA; ENSG00000167549; Group enriched (skeletal muscle, tongue).
DR neXtProt; NX_Q6QEF8; -.
DR OpenTargets; ENSG00000167549; -.
DR PharmGKB; PA134869901; -.
DR VEuPathDB; HostDB:ENSG00000167549; -.
DR eggNOG; KOG0303; Eukaryota.
DR GeneTree; ENSGT00940000159328; -.
DR InParanoid; Q6QEF8; -.
DR OMA; FRHSTGH; -.
DR OrthoDB; 552726at2759; -.
DR PhylomeDB; Q6QEF8; -.
DR TreeFam; TF314280; -.
DR PathwayCommons; Q6QEF8; -.
DR SignaLink; Q6QEF8; -.
DR BioGRID-ORCS; 84940; 22 hits in 1067 CRISPR screens.
DR ChiTaRS; CORO6; human.
DR GenomeRNAi; 84940; -.
DR Pharos; Q6QEF8; Tdark.
DR PRO; PR:Q6QEF8; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6QEF8; protein.
DR Bgee; ENSG00000167549; Expressed in gastrocnemius and 141 other tissues.
DR ExpressionAtlas; Q6QEF8; baseline and differential.
DR Genevisible; Q6QEF8; HS.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR027337; CORO6.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR PANTHER; PTHR10856:SF23; PTHR10856:SF23; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..472
FT /note="Coronin-6"
FT /id="PRO_0000259596"
FT REPEAT 23..64
FT /note="WD 1"
FT REPEAT 72..111
FT /note="WD 2"
FT REPEAT 122..161
FT /note="WD 3"
FT REPEAT 165..204
FT /note="WD 4"
FT REPEAT 210..251
FT /note="WD 5"
FT REPEAT 256..296
FT /note="WD 6"
FT REGION 407..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 430..464
FT /evidence="ECO:0000255"
FT COMPBIAS 419..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..251
FT /note="MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVE
FT AGGGGAFIVLPLAKTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQI
FT PDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSL
FT DDMHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEQARPHEGARPLRAVFTA
FT DGKLLSTGFSRMSERQLALWDP -> MCRGGGAMCAGEEERCAQGRGLQLWSLEVWGIG
FT FGKARKRKGASGGPEVAREGGAGLVTPPVLGQ (in isoform 2 and isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15498874, ECO:0000303|Ref.2"
FT /id="VSP_021484"
FT VAR_SEQ 1..251
FT /note="MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVE
FT AGGGGAFIVLPLAKTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQI
FT PDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSL
FT DDMHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEQARPHEGARPLRAVFTA
FT DGKLLSTGFSRMSERQLALWDP -> MPSPWGWFAVTACGAQR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15498874"
FT /id="VSP_021485"
FT VAR_SEQ 213..247
FT /note="QARPHEGARPLRAVFTADGKLLSTGFSRMSERQLA -> RFAAHEGMRPMRA
FT VFTRQGHIFTTGFTRMSQRELG (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039874"
FT VAR_SEQ 433
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:15498874"
FT /id="VSP_021486"
FT CONFLICT 266
FT /note="S -> I (in Ref. 3; BAG53288)"
FT /evidence="ECO:0000305"
FT TURN 10..13
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 15..18
FT /evidence="ECO:0007829|PDB:7KYX"
FT HELIX 21..23
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 24..27
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 39..42
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 44..51
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 58..63
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 84..89
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 96..101
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 106..110
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 124..127
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 134..139
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 141..143
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 146..151
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 156..160
FT /evidence="ECO:0007829|PDB:7KYX"
FT TURN 161..163
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 166..170
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 172..176
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 178..183
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 190..194
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 199..203
FT /evidence="ECO:0007829|PDB:7KYX"
FT TURN 204..207
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 208..212
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 221..227
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 233..238
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 244..249
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 258..262
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 271..275
FT /evidence="ECO:0007829|PDB:7KYX"
FT TURN 276..279
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 280..284
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 291..296
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 302..309
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 316..320
FT /evidence="ECO:0007829|PDB:7KYX"
FT HELIX 323..325
FT /evidence="ECO:0007829|PDB:7KYX"
FT HELIX 328..330
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 332..339
FT /evidence="ECO:0007829|PDB:7KYX"
FT STRAND 341..350
FT /evidence="ECO:0007829|PDB:7KYX"
FT TURN 360..362
FT /evidence="ECO:0007829|PDB:7KYX"
FT HELIX 375..379
FT /evidence="ECO:0007829|PDB:7KYX"
FT HELIX 391..393
FT /evidence="ECO:0007829|PDB:7KYX"
SQ SEQUENCE 472 AA; 52762 MW; A49F939A4CD40A18 CRC64;
MSRRVVRQSK FRHVFGQAAK ADQAYEDIRV SKVTWDSSFC AVNPKFLAII VEAGGGGAFI
VLPLAKTGRV DKNYPLVTGH TAPVLDIDWC PHNDNVIASA SDDTTIMVWQ IPDYTPMRNI
TEPIITLEGH SKRVGILSWH PTARNVLLSA GGDNVIIIWN VGTGEVLLSL DDMHPDVIHS
VCWNSNGSLL ATTCKDKTLR IIDPRKGQVV AEQARPHEGA RPLRAVFTAD GKLLSTGFSR
MSERQLALWD PNNFEEPVAL QEMDTSNGVL LPFYDPDSSI VYLCGKGDSS IRYFEITDEP
PFVHYLNTFS SKEPQRGMGF MPKRGLDVSK CEIARFYKLH ERKCEPIIMT VPRKSDLFQD
DLYPDTPGPE PALEADEWLS GQDAEPVLIS LRDGYVPPKH RELRVTKRNI LDVRPPSGPR
RSQSASDAPL SQQHTLETLL EEIKALRERV QAQEQRITAL ENMLCELVDG TD
