CORO6_MOUSE
ID CORO6_MOUSE Reviewed; 471 AA.
AC Q920M5; Q3TZ14; Q5F262; Q5F263; Q5F264; Q5F265; Q920M3; Q920M4;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Coronin-6;
DE AltName: Full=Coronin-like protein E;
DE Short=Clipin-E;
GN Name=Coro6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
RC STRAIN=ICR; TISSUE=Brain;
RA Watanabe N., Takeuchi K., Kusumi A.;
RT "Expression and function of mammalian clipin E/coronin 6.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RC STRAIN=C57BL/6J; TISSUE=Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=A;
CC IsoId=Q920M5-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q920M5-2; Sequence=VSP_011749;
CC Name=C;
CC IsoId=Q920M5-3; Sequence=VSP_011750;
CC Name=D;
CC IsoId=Q920M5-4; Sequence=VSP_011749, VSP_021487;
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DR EMBL; AB070894; BAB64361.1; -; mRNA.
DR EMBL; AB070895; BAB64362.1; -; mRNA.
DR EMBL; AB070896; BAB64363.1; -; mRNA.
DR EMBL; AK158179; BAE34396.1; -; mRNA.
DR EMBL; AL607072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS25077.1; -. [Q920M5-1]
DR CCDS; CCDS25078.1; -. [Q920M5-3]
DR CCDS; CCDS25079.1; -. [Q920M5-2]
DR RefSeq; NP_624354.1; NM_139128.1. [Q920M5-1]
DR RefSeq; NP_624355.1; NM_139129.1. [Q920M5-3]
DR RefSeq; NP_624356.1; NM_139130.2. [Q920M5-2]
DR RefSeq; XP_006533000.1; XM_006532937.1.
DR RefSeq; XP_006533002.1; XM_006532939.1. [Q920M5-4]
DR RefSeq; XP_006533003.1; XM_006532940.1. [Q920M5-4]
DR RefSeq; XP_006533004.1; XM_006532941.1. [Q920M5-4]
DR RefSeq; XP_006533005.1; XM_006532942.1. [Q920M5-4]
DR RefSeq; XP_006533007.1; XM_006532944.1. [Q920M5-2]
DR RefSeq; XP_006533008.1; XM_006532945.2. [Q920M5-1]
DR RefSeq; XP_006533010.1; XM_006532947.2. [Q920M5-3]
DR RefSeq; XP_017169950.1; XM_017314461.1. [Q920M5-4]
DR AlphaFoldDB; Q920M5; -.
DR SMR; Q920M5; -.
DR BioGRID; 229821; 1.
DR STRING; 10090.ENSMUSP00000021190; -.
DR iPTMnet; Q920M5; -.
DR PhosphoSitePlus; Q920M5; -.
DR MaxQB; Q920M5; -.
DR PaxDb; Q920M5; -.
DR PRIDE; Q920M5; -.
DR ProteomicsDB; 284094; -. [Q920M5-1]
DR ProteomicsDB; 284095; -. [Q920M5-2]
DR ProteomicsDB; 284096; -. [Q920M5-3]
DR ProteomicsDB; 284097; -. [Q920M5-4]
DR Antibodypedia; 54318; 127 antibodies from 17 providers.
DR DNASU; 216961; -.
DR Ensembl; ENSMUST00000021190; ENSMUSP00000021190; ENSMUSG00000020836. [Q920M5-1]
DR Ensembl; ENSMUST00000079770; ENSMUSP00000078703; ENSMUSG00000020836. [Q920M5-3]
DR Ensembl; ENSMUST00000102493; ENSMUSP00000099551; ENSMUSG00000020836. [Q920M5-2]
DR Ensembl; ENSMUST00000108391; ENSMUSP00000104028; ENSMUSG00000020836. [Q920M5-2]
DR GeneID; 216961; -.
DR KEGG; mmu:216961; -.
DR UCSC; uc007kgq.1; mouse. [Q920M5-3]
DR UCSC; uc007kgr.1; mouse. [Q920M5-2]
DR UCSC; uc007kgs.1; mouse. [Q920M5-1]
DR CTD; 84940; -.
DR MGI; MGI:2183448; Coro6.
DR VEuPathDB; HostDB:ENSMUSG00000020836; -.
DR eggNOG; KOG0303; Eukaryota.
DR GeneTree; ENSGT00940000159328; -.
DR HOGENOM; CLU_026859_0_1_1; -.
DR InParanoid; Q920M5; -.
DR OMA; FRHSTGH; -.
DR OrthoDB; 552726at2759; -.
DR PhylomeDB; Q920M5; -.
DR TreeFam; TF314280; -.
DR BioGRID-ORCS; 216961; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Coro6; mouse.
DR PRO; PR:Q920M5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q920M5; protein.
DR Bgee; ENSMUSG00000020836; Expressed in interventricular septum and 156 other tissues.
DR ExpressionAtlas; Q920M5; baseline and differential.
DR Genevisible; Q920M5; MM.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR027337; CORO6.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR PANTHER; PTHR10856:SF23; PTHR10856:SF23; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..471
FT /note="Coronin-6"
FT /id="PRO_0000050932"
FT REPEAT 79..119
FT /note="WD 1"
FT REPEAT 129..169
FT /note="WD 2"
FT REPEAT 173..212
FT /note="WD 3"
FT REPEAT 216..259
FT /note="WD 4"
FT REPEAT 264..304
FT /note="WD 5"
FT REGION 410..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 426..468
FT /evidence="ECO:0000255"
FT COMPBIAS 419..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 212..251
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_011750"
FT VAR_SEQ 214..247
FT /note="ARPHEGARPLRAVFTADGKLLSTGFSRMSERQLA -> FAAHEGMRPMRAVF
FT TRLGHIFTTGFTRMSQRELG (in isoform B and isoform D)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_011749"
FT VAR_SEQ 432
FT /note="Q -> QQ (in isoform D)"
FT /evidence="ECO:0000305"
FT /id="VSP_021487"
SQ SEQUENCE 471 AA; 52599 MW; 4C5D043454E0F007 CRC64;
MSRRVVRQSK FRHVFGQAAK ADQAYEDIRV SKVTWDSAFC AVNPKFLAII VEAGGGGAFI
VLPLAKTGRV DKNYPLVTGH TGPVLDIDWC PHNDNVIASA SDDTTVMVWQ IPDYTPVRNI
TEPVITLEGH SKRVGILSWH PTARNVLLSA GGDNVIIIWN VGTGEVLLSL DDIHPDVIHS
VCWNSNGSLL ATTCKDKTLR IIDPRKSQVV AERARPHEGA RPLRAVFTAD GKLLSTGFSR
MSERQLALWD PNNFEEPVAL QEMDTSNGVL LPFYDPDSSI VYLCGKGDSS IRYFEITEEP
PFVHYLNTFS SKEPQRGMGF MPKRGLDVSK CEIARFYKLH ERKCEPIIMT VPRKSDLFQD
DLYPDTPGPE PALEADEWLS GQDAEPVLIS LKEGYVPPKH RELRVTKRNI LDVRPPASPR
RSQSASEAPL SQHTLETLLE EIKALRDRVQ AQEERITALE NMLCELVDGT D
