COROA_DICDI
ID COROA_DICDI Reviewed; 445 AA.
AC P27133; Q55G40;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Coronin-A;
DE AltName: Full=Coronin;
DE AltName: Full=p55;
GN Name=corA; ORFNames=DDB_G0267382;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 174-198 AND 266-286.
RC STRAIN=AX2;
RX PubMed=1661669;
RA de Hostos E.L., Bradtke B., Lottspeich F., Guggenheim R., Gerisch G.;
RT "Coronin, an actin binding protein of Dictyostelium discoideum localized to
RT cell surface projections, has sequence similarities to G protein beta
RT subunits.";
RL EMBO J. 10:4097-4104(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Required for normal motility. Participates in cytokinesis.
CC -!- SUBUNIT: Binds to F-actin.
CC -!- SUBCELLULAR LOCATION: Cell surface. Note=On crown-like cell surface
CC projections.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
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DR EMBL; X61480; CAA43707.1; -; mRNA.
DR EMBL; AAFI02000003; EAL73143.1; -; Genomic_DNA.
DR PIR; S18663; S18663.
DR RefSeq; XP_647343.1; XM_642251.1.
DR AlphaFoldDB; P27133; -.
DR SMR; P27133; -.
DR BioGRID; 1241156; 45.
DR STRING; 44689.DDB0191115; -.
DR PaxDb; P27133; -.
DR PRIDE; P27133; -.
DR ABCD; P27133; 2 sequenced antibodies.
DR EnsemblProtists; EAL73143; EAL73143; DDB_G0267382.
DR GeneID; 8616153; -.
DR KEGG; ddi:DDB_G0267382; -.
DR dictyBase; DDB_G0267382; corA.
DR eggNOG; KOG0303; Eukaryota.
DR HOGENOM; CLU_026859_0_0_1; -.
DR InParanoid; P27133; -.
DR OMA; FRHSTGH; -.
DR PhylomeDB; P27133; -.
DR PRO; PR:P27133; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0015629; C:actin cytoskeleton; IDA:dictyBase.
DR GO; GO:0061802; C:anterior cell cortex; IDA:dictyBase.
DR GO; GO:0005938; C:cell cortex; IDA:dictyBase.
DR GO; GO:0060187; C:cell pole; IDA:dictyBase.
DR GO; GO:0042995; C:cell projection; IDA:dictyBase.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0051286; C:cell tip; IDA:dictyBase.
DR GO; GO:0032154; C:cleavage furrow; IDA:dictyBase.
DR GO; GO:0030863; C:cortical cytoskeleton; IDA:dictyBase.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0061836; C:intranuclear rod; IDA:dictyBase.
DR GO; GO:1990537; C:mitotic spindle polar microtubule; IDA:dictyBase.
DR GO; GO:0140220; C:pathogen-containing vacuole; IDA:dictyBase.
DR GO; GO:0001891; C:phagocytic cup; IDA:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IDA:dictyBase.
DR GO; GO:0061803; C:posterior cell cortex; IDA:dictyBase.
DR GO; GO:0031982; C:vesicle; IDA:dictyBase.
DR GO; GO:0051015; F:actin filament binding; IDA:dictyBase.
DR GO; GO:0043621; F:protein self-association; IPI:dictyBase.
DR GO; GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.
DR GO; GO:0030042; P:actin filament depolymerization; IGI:dictyBase.
DR GO; GO:0007015; P:actin filament organization; IGI:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR GO; GO:0042742; P:defense response to bacterium; IMP:dictyBase.
DR GO; GO:0006897; P:endocytosis; TAS:dictyBase.
DR GO; GO:0010467; P:gene expression; IMP:dictyBase.
DR GO; GO:0006972; P:hyperosmotic response; IEP:dictyBase.
DR GO; GO:1905861; P:intranuclear rod assembly; IGI:dictyBase.
DR GO; GO:1903673; P:mitotic cleavage furrow formation; IGI:dictyBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR GO; GO:0006909; P:phagocytosis; IMP:dictyBase.
DR GO; GO:0043521; P:regulation of myosin II filament disassembly; IMP:dictyBase.
DR GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
DR GO; GO:1904643; P:response to curcumin; IDA:dictyBase.
DR GO; GO:0009991; P:response to extracellular stimulus; IMP:dictyBase.
DR GO; GO:0051707; P:response to other organism; TAS:dictyBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Coiled coil; Direct protein sequencing; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..445
FT /note="Coronin-A"
FT /id="PRO_0000050938"
FT REPEAT 77..117
FT /note="WD 1"
FT REPEAT 127..167
FT /note="WD 2"
FT REPEAT 170..209
FT /note="WD 3"
FT REPEAT 259..299
FT /note="WD 4"
FT COILED 410..444
FT /evidence="ECO:0000255"
FT CONFLICT 138
FT /note="N -> G (in Ref. 1; CAA43707)"
FT /evidence="ECO:0000305"
FT CONFLICT 355
FT /note="D -> G (in Ref. 1; CAA43707)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 445 AA; 49215 MW; 0F380E520C6365A5 CRC64;
MSKVVRSSKY RHVFAAQPKK EECYQNLKVT KSAWDSNYVA ANTRYFGVIW DAAGGGSFAV
IPHEASGKTT SVPLFNGHKS AVLDIAFHPF NENLVGSVSE DCNICIWGIP EGGLTDSIST
PLQTLSGHKR KVGTISFNPV ADNVAVTSSG DFLVKTWDVE QGKNLTTVEG HSDMITSCEW
NHNGSQIVTT CKDKKARVFD PRTNSIVNEV VCHQGVKNSR AIFAKDKVIT VGFSKTSERE
LHIYDPRAFT TPLSAQVVDS ASGLLMPFYD ADNSILYLAG KGDGNIRYYE LVDESPYIHF
LSEFKSATPQ RGLCFLPKRC LNTSECEIAR GLKVTPFTVE PISFRVPRKS DIFQDDIYPD
TYAGEPSLTA EQWVSGTNAE PKTVSLAGGF VKKASAVEFK PVVQVQEGPK NEKELREEYE
KLKIRVAYLE SEIVKKDAKI KELTN
