COROB_DICDI
ID COROB_DICDI Reviewed; 962 AA.
AC Q55E54;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Coronin-B;
DE AltName: Full=Coronin-7;
DE Short=DdCRN7;
DE AltName: Full=Doublecoronin;
GN Name=corB; Synonyms=cor7; ORFNames=DDB_G0269388;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, INTERACTION WITH
RP F-ACTIN, DEVELOPMENTAL STAGE, AND SUBUNIT.
RX PubMed=20071332; DOI=10.1074/jbc.m109.083725;
RA Shina M.C., Unal C., Eichinger L., Muller-Taubenberger A., Schleicher M.,
RA Steinert M., Noegel A.A.;
RT "A Coronin7 homolog with functions in actin-driven processes.";
RL J. Biol. Chem. 285:9249-9261(2010).
CC -!- FUNCTION: Involved in phagocytosis and cell motility. Binds to actin
CC filaments and protects them against depolymerization.
CC {ECO:0000269|PubMed:20071332}.
CC -!- SUBUNIT: Monomer. Binds to F-actin. {ECO:0000269|PubMed:20071332}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20071332}. Cell
CC projection {ECO:0000269|PubMed:20071332}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:20071332}. Cytoplasm, cell cortex
CC {ECO:0000269|PubMed:20071332}. Note=Accumulates in cell surface
CC projections during movement, phagocytosis and pinocytosis. Detected at
CC the leading edge of the cell during chemotaxis.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development.
CC {ECO:0000269|PubMed:20071332}.
CC -!- DOMAIN: Seems to consist of two repeat of a full-length coronin.
CC -!- DISRUPTION PHENOTYPE: Shows altered chemotaxis and phagocytosis. Cells
CC are slightly smaller, grow more slowly and do not reach the same final
CC density at stationary phase. Affects the infection process by the
CC pathogen L.pneumophila and allows a more efficient internalization of
CC bacteria. Allows a more efficient uptake of dead yeast cells.
CC {ECO:0000269|PubMed:20071332}.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72044.1; -; Genomic_DNA.
DR RefSeq; XP_645927.1; XM_640835.1.
DR AlphaFoldDB; Q55E54; -.
DR STRING; 44689.DDB0232260; -.
DR PaxDb; Q55E54; -.
DR EnsemblProtists; EAL72044; EAL72044; DDB_G0269388.
DR GeneID; 8616868; -.
DR KEGG; ddi:DDB_G0269388; -.
DR dictyBase; DDB_G0269388; corB.
DR eggNOG; KOG1445; Eukaryota.
DR HOGENOM; CLU_006604_0_0_1; -.
DR InParanoid; Q55E54; -.
DR OMA; VMQGEVN; -.
DR PhylomeDB; Q55E54; -.
DR PRO; PR:Q55E54; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IDA:dictyBase.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0001891; C:phagocytic cup; IDA:dictyBase.
DR GO; GO:0051015; F:actin filament binding; IDA:dictyBase.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0001667; P:ameboidal-type cell migration; IMP:dictyBase.
DR GO; GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IMP:dictyBase.
DR GO; GO:0120320; P:lateral pseudopodium retraction; IMP:dictyBase.
DR GO; GO:0030835; P:negative regulation of actin filament depolymerization; IDA:dictyBase.
DR GO; GO:0006909; P:phagocytosis; IMP:dictyBase.
DR GO; GO:0009617; P:response to bacterium; IMP:dictyBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR Pfam; PF08953; DUF1899; 2.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM01166; DUF1899; 2.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Actin-binding; Cell projection; Cytoplasm; Cytoskeleton; Phagocytosis;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..962
FT /note="Coronin-B"
FT /id="PRO_0000327593"
FT REPEAT 74..114
FT /note="WD 1"
FT REPEAT 126..166
FT /note="WD 2"
FT REPEAT 169..208
FT /note="WD 3"
FT REPEAT 212..255
FT /note="WD 4"
FT REPEAT 260..300
FT /note="WD 5"
FT REPEAT 557..597
FT /note="WD 6"
FT REPEAT 614..654
FT /note="WD 7"
FT REPEAT 660..699
FT /note="WD 8"
FT REPEAT 717..748
FT /note="WD 9"
FT REPEAT 755..795
FT /note="WD 10"
FT REGION 1..438
FT /note="Coronin 1"
FT REGION 417..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..483
FT /note="Linker"
FT REGION 484..962
FT /note="Coronin 2"
FT REGION 910..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 105955 MW; 1545D71B703C1D96 CRC64;
MFKVSKYRHT VGKIDKRELW YPDVNTTGNS SASTFIKANS KWVALNWQSN TGTIGLIPLK
SFGKRKGETF LIHAHSSGVI DFEFNPFNEH QLVTASDDST IKVWNIDEAI RSGATSLSSA
SIVCSGHSKS VECIAFNPVA NNILASCSAD KTLKIWDLSN GEEKYSWNFE QGSLTSLSWN
YDGSLLVATG KDLKNRIIDA RTGESIQVGD GNQGVKASRV VWLGNLNHFL TAGFSKMRER
QLVLWSSQDL SKPIKSITLD SSTGIISPIY DQDAQLLFIS GSGDSSVRVF DMNTQFTKDP
AFTELSPVPS DTPSKGICAL PKRALDVMEV EIDRIFKATP NNIIPITFNM SRKSKSTFAD
DLFPNTASTK PSLSSIDWLS GENKQPILVS LNPSDNQINN DLDDLQLNDN EPVKKSTFFI
DDNTNDNSNV VEQSKSEPEQ QQQEEKKISS SSSSSSPTNS SSNVINSTPS SPIVNDNIQR
TGIVPKVVRS SKYRHISGSA HQKSQFYTNL KINGSTSNTC IAVNSEYVAV PMVGIGGPLA
VIPLADKGRQ IQVPCIEIGS QLCDYDLSQH NTSLVATGSE DSHVKVFKIP TGGIPKTTAN
KSNNYTTTEA DFVGHNRKVI SVNFHPTAEN VLITSGGDMV VKLWDLNEGG AGEKLSFANV
HTDMITSVDV NWTGDKILTS SKDKKMRIFD PRTNKGGLAS ETVTHSGSKG GKAVWLGQTG
NIFSVGFNKS SEREYQLWDS RNLQSGTPLA SDKLDHLSGV ITPFYDEDSG VIYLAGKGDS
SIRMFEINDQ EPYVHYLTQF SAGTPQVGVA KFAKKTSMDV KKCEIARFYR STDSTIEPLS
MTVPRNRQEF FQDDIYPDTR QTCTPVMTSE EWFDGCIREP EFVSMKPSDM INLSDAPPPP
KKEDKFVVSQ EVDNTPSRDQ VTNSLLSRVS NQNASSNWEQ IEKLKHNFTD YDNGDISDSE
WD
