CORO_CAEEL
ID CORO_CAEEL Reviewed; 607 AA.
AC Q21624; Q8T3D5; Q8T3D6; Q8T3D7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Coronin-like protein cor-1;
GN Name=cor-1; ORFNames=R01H10.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=23784779; DOI=10.1073/pnas.1301849110;
RA Wang X., Zhou F., Lv S., Yi P., Zhu Z., Yang Y., Feng G., Li W., Ou G.;
RT "Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the
RT cell polarity in neuronal migration.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:11175-11180(2013).
CC -!- FUNCTION: Required to direct the migration of Q neuroblasts along the
CC anterior axis of the body during larval development. This is dependent
CC on its asymmetric expression in Q neuroblasts.
CC {ECO:0000269|PubMed:23784779}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:23784779}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=c;
CC IsoId=Q21624-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q21624-2; Sequence=VSP_020792;
CC Name=b;
CC IsoId=Q21624-3; Sequence=VSP_020790;
CC Name=d;
CC IsoId=Q21624-4; Sequence=VSP_020789, VSP_020791;
CC -!- DEVELOPMENTAL STAGE: Asymmetrically expressed in Q neuroblasts during
CC larval development. Highly expressed at the leading edge of migrating Q
CC neuroblasts. {ECO:0000269|PubMed:23784779}.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z31590; CAA83461.1; -; Genomic_DNA.
DR EMBL; Z31590; CAD27604.1; -; Genomic_DNA.
DR EMBL; Z31590; CAD27605.1; -; Genomic_DNA.
DR EMBL; Z31590; CAD27606.1; -; Genomic_DNA.
DR PIR; S43568; S43568.
DR RefSeq; NP_741268.1; NM_171226.3. [Q21624-1]
DR RefSeq; NP_741269.1; NM_171892.5. [Q21624-2]
DR RefSeq; NP_741270.1; NM_171893.3. [Q21624-3]
DR RefSeq; NP_741271.1; NM_171227.3.
DR AlphaFoldDB; Q21624; -.
DR SMR; Q21624; -.
DR BioGRID; 41634; 3.
DR IntAct; Q21624; 1.
DR STRING; 6239.R01H10.3c; -.
DR EPD; Q21624; -.
DR PaxDb; Q21624; -.
DR PeptideAtlas; Q21624; -.
DR EnsemblMetazoa; R01H10.3a.1; R01H10.3a.1; WBGene00000768. [Q21624-2]
DR EnsemblMetazoa; R01H10.3b.1; R01H10.3b.1; WBGene00000768. [Q21624-3]
DR EnsemblMetazoa; R01H10.3c.1; R01H10.3c.1; WBGene00000768. [Q21624-1]
DR GeneID; 176440; -.
DR KEGG; cel:CELE_R01H10.3; -.
DR UCSC; R01H10.3d; c. elegans. [Q21624-1]
DR CTD; 176440; -.
DR WormBase; R01H10.3a; CE00590; WBGene00000768; cor-1. [Q21624-2]
DR WormBase; R01H10.3b; CE30350; WBGene00000768; cor-1. [Q21624-3]
DR WormBase; R01H10.3c; CE30351; WBGene00000768; cor-1. [Q21624-1]
DR WormBase; R01H10.3d; CE30352; WBGene00000768; cor-1. [Q21624-4]
DR eggNOG; KOG0303; Eukaryota.
DR GeneTree; ENSGT00940000168719; -.
DR InParanoid; Q21624; -.
DR OMA; MVMVWEI; -.
DR OrthoDB; 552726at2759; -.
DR PhylomeDB; Q21624; -.
DR PRO; PR:Q21624; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000768; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..607
FT /note="Coronin-like protein cor-1"
FT /id="PRO_0000050937"
FT REPEAT 77..117
FT /note="WD 1"
FT REPEAT 127..167
FT /note="WD 2"
FT REPEAT 170..209
FT /note="WD 3"
FT REGION 415..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 563..602
FT /evidence="ECO:0000255"
FT COMPBIAS 415..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 491..495
FT /note="KQAVQ -> MRTTL (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_020789"
FT VAR_SEQ 494..562
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020790"
FT VAR_SEQ 496..607
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_020791"
FT VAR_SEQ 561..562
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_020792"
SQ SEQUENCE 607 AA; 67217 MW; 0090126B0D045BF9 CRC64;
MAQIVRQSKF RHVFCKPVKH ESCMSDIRVT EITWDSLFCD VNPKFIAFIN RGAGGPFMVI
PVNKIGRVDK DYPFVDAHKA PCLEVAWSPF NDNVIASCSE DTTCKVWVIP DRGLNRNLSE
PAVELTGHQK RVNTIAWHPV ANNVLLTAGG ENVMFMWNVG TGEALLEISG HPDQIWSINF
NFDGSQFVTT CKDKKIRILD SHTGEVVHEG MGHEGVKPQR AIFVKDGLIL STGFTKRSER
LYALRAPEDL STPIVEEELD TSNGVVFPFY DEDSGLVYLV GKGDCAIRYY EVNNDAPYVH
YINTYTTNEP QRAVGFQSKR GMSSEENEIN RIYKLTTKGV VDILQFFVPR KSDLFQHDLY
PDTRSTIPAL TAEEFMEGKN AAPNRQPVNA AAAAAAAKPK VQVAKKANIL STLAPTAAES
VPTQSYSERP PSSQQPSPRP SASPRPRPVV DDDMGIVTMR EAPPSRPASS RASRTEIPPK
EESKVDPMKP KQAVQLKSRA ARDEPGGGAQ TAGQRRAAAE LERIKRDQSR TADEDNTLAP
PPSSSRASAS PRGSVSAASD VGHVPQNMDE LLEDLMKMKA VLRQHERRIR MLEEEIADRN
MSNAYSF
