CORT_MOUSE
ID CORT_MOUSE Reviewed; 109 AA.
AC P56469; A2AH76; Q9R1P8;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Cortistatin;
DE Contains:
DE RecName: Full=Cortistatin-14;
DE Flags: Precursor;
GN Name=Cort;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=9205124; DOI=10.1006/geno.1997.4763;
RA de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E.,
RA Frankel W.N., Sutcliffe J.G.;
RT "Cloning, mRNA expression, and chromosomal mapping of mouse and human
RT preprocortistatin.";
RL Genomics 42:499-506(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC STRAIN=129/Sv;
RX PubMed=10521599; DOI=10.1016/s0169-328x(99)00220-x;
RA Calbet M., Guadano-Ferraz A., Spier A.D., Maj M., Sutcliffe J.G.,
RA Przewlocki R., de Lecea L.;
RT "Cortistatin and somatostatin mRNAs are differentially regulated in
RT response to kainate.";
RL Brain Res. Mol. Brain Res. 72:55-64(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of GABAergic cells in the
CC cortex and hippocampus.
CC -!- INDUCTION: Not induced by kainate. {ECO:0000269|PubMed:10521599}.
CC -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR EMBL; AF013253; AAB66896.1; -; mRNA.
DR EMBL; AF050156; AAD51127.1; -; Genomic_DNA.
DR EMBL; AK013496; BAB28882.1; -; mRNA.
DR EMBL; AL731655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18953.1; -.
DR RefSeq; NP_031771.1; NM_007745.4.
DR AlphaFoldDB; P56469; -.
DR STRING; 10090.ENSMUSP00000030815; -.
DR PhosphoSitePlus; P56469; -.
DR PaxDb; P56469; -.
DR PRIDE; P56469; -.
DR Antibodypedia; 57276; 52 antibodies from 12 providers.
DR DNASU; 12854; -.
DR Ensembl; ENSMUST00000030815; ENSMUSP00000030815; ENSMUSG00000028971.
DR GeneID; 12854; -.
DR KEGG; mmu:12854; -.
DR UCSC; uc008vvs.1; mouse.
DR CTD; 1325; -.
DR MGI; MGI:109538; Cort.
DR VEuPathDB; HostDB:ENSMUSG00000028971; -.
DR eggNOG; ENOG502S1NT; Eukaryota.
DR GeneTree; ENSGT00730000111752; -.
DR HOGENOM; CLU_124515_0_0_1; -.
DR InParanoid; P56469; -.
DR OMA; SGHMQEV; -.
DR OrthoDB; 1614009at2759; -.
DR PhylomeDB; P56469; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 12854; 1 hit in 70 CRISPR screens.
DR PRO; PR:P56469; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P56469; protein.
DR Bgee; ENSMUSG00000028971; Expressed in embryonic brain and 64 other tissues.
DR Genevisible; P56469; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISO:MGI.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:MGI.
DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; ISO:MGI.
DR InterPro; IPR004250; Somatostatin.
DR InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR Pfam; PF03002; Somatostatin; 1.
DR PIRSF; PIRSF001814; Somatostatin; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..93
FT /evidence="ECO:0000255"
FT /id="PRO_0000033157"
FT PEPTIDE 96..109
FT /note="Cortistatin-14"
FT /id="PRO_0000033158"
FT REGION 64..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 97..108
FT /evidence="ECO:0000250"
FT CONFLICT 40
FT /note="Missing (in Ref. 2; AAD51127)"
FT /evidence="ECO:0000305"
FT CONFLICT 57..59
FT /note="Missing (in Ref. 2; AAD51127)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 109 AA; 11613 MW; 630D3BDD0488F722 CRC64;
MMGGRGTGGK WPSAFGLLLL WGVAASALPL ESGPTGQDSV QEATEGRSGL LTFLAWWHEW
ASQASSSTPV GGGTPGLSKS QERPPPQQPP HLDKKPCKNF FWKTFSSCK
