ID   CORT_RAT                Reviewed;         112 AA.
AC   Q62949;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Cortistatin;
DE   Contains:
DE     RecName: Full=Cortistatin-29;
DE   Contains:
DE     RecName: Full=Cortistatin-14;
DE   Flags: Precursor;
GN   Name=Cort;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 99-112.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=8622767; DOI=10.1038/381242a0;
RA   de Lecea L., Criado J.R., Prospero-Garcia O., Gautvik K.M., Schweitzer P.,
RA   Danielson P.E., Dunlop C.L.M., Siggins G.R., Henriksen S.J.,
RA   Sutcliffe J.G.;
RT   "A cortical neuropeptide with neuronal depressant and sleep-modulating
RT   properties.";
RL   Nature 381:242-245(1996).
CC   -!- FUNCTION: Neuropeptide with neuronal depressant and sleep-modulating
CC       properties.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Interneurons in the cerebral cortex and
CC       hippocampus.
CC   -!- DEVELOPMENTAL STAGE: There is a transient increase in cortistatin-
CC       expressing cells in the second postnatal week in all cortical areas and
CC       in the dentate gyrus. A transient expression is observed in the hilar
CC       region at P16.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; U51919; AAC52585.1; -; mRNA.
DR   PIR; S67489; S67489.
DR   RefSeq; NP_036967.1; NM_012835.1.
DR   AlphaFoldDB; Q62949; -.
DR   GeneID; 25305; -.
DR   KEGG; rno:25305; -.
DR   UCSC; RGD:2383; rat.
DR   CTD; 1325; -.
DR   RGD; 2383; Cort.
DR   OrthoDB; 1614009at2759; -.
DR   PhylomeDB; Q62949; -.
DR   PRO; PR:Q62949; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:RGD.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IDA:RGD.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:RGD.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:RGD.
DR   GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IDA:RGD.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PROPEP          28..81
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033159"
FT   PEPTIDE         84..112
FT                   /note="Cortistatin-29"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033160"
FT   PEPTIDE         99..112
FT                   /note="Cortistatin-14"
FT                   /id="PRO_0000033161"
FT   REGION          66..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        100..111
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   112 AA;  12201 MW;  FF1FBFC76CBD7991 CRC64;
     MGGCSTRGKR PSALSLLLLL LLSGIAASAL PLESGPTGQD SVQDATGGRR TGLLTFLAWW
     HEWASQDSSS TAFEGGTPEL SKRQERPPLQ QPPHRDKKPC KNFFWKTFSS CK