ID   CORZ_AEDAE              Reviewed;         137 AA.
AC   Q17AN4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Pro-corazonin;
DE            Short=Crz;
DE   Contains:
DE     RecName: Full=Corazonin;
DE   Contains:
DE     RecName: Full=Corazonin precursor-related peptide;
DE              Short=CPRP;
DE   Flags: Precursor;
GN   Name=Crz {ECO:0000250|UniProtKB:Q26377}; ORFNames=AAEL005252;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT43308.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC       physiological regulation of the heart beat (By similarity).
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin precursor-related peptide]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
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DR   EMBL; CH477332; EAT43308.1; -; Genomic_DNA.
DR   RefSeq; XP_001650567.1; XM_001650517.1.
DR   AlphaFoldDB; Q17AN4; -.
DR   STRING; 7159.AAEL005252-PA; -.
DR   VEuPathDB; VectorBase:AAEL005252; -.
DR   eggNOG; ENOG502T8PQ; Eukaryota.
DR   HOGENOM; CLU_1866778_0_0_1; -.
DR   InParanoid; Q17AN4; -.
DR   OrthoDB; 1626389at2759; -.
DR   PhylomeDB; Q17AN4; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0071858; F:corazonin receptor binding; IEA:InterPro.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
DR   InterPro; IPR020190; Procorazonin.
DR   Pfam; PF17308; Corazonin; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT   CHAIN           21..137
FT                   /note="Pro-corazonin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000341605"
FT   PEPTIDE         21..31
FT                   /note="Corazonin"
FT                   /id="PRO_0000341489"
FT   PEPTIDE         35..66
FT                   /note="Corazonin precursor-related peptide"
FT                   /id="PRO_0000341490"
FT   PROPEP          68..137
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT                   /id="PRO_0000341491"
FT   MOD_RES         21
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT   MOD_RES         31
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
SQ   SEQUENCE   137 AA;  15559 MW;  612DFF2692AF5B09 CRC64;
     MKHVFSTSLI VSLFVIFTDA QTFQYSRGWT NGKRSSPEQT APSRTLLPHI PLGMDKPDEE
     CRLLIQRFLK SPCDVRLANA IVNRNKDLLR DMADDVNDGT ALLYDPVPMV DTAASEDVRF
     KRGTPDRRLL NDGMHRL