ID   CORZ_AGRIP              Reviewed;         103 AA.
AC   C0HKT2;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Pro-corazonin {ECO:0000250|UniProtKB:Q26377};
DE   Contains:
DE     RecName: Full=Corazonin {ECO:0000303|PubMed:29466015};
DE   Flags: Precursor;
OS   Agrotis ipsilon (Black cutworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Noctuinae; Noctuini; Agrotis.
OX   NCBI_TaxID=56364;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-30, TISSUE SPECIFICITY,
RP   MASS SPECTROMETRY, IDENTIFICATION BY MASS SPECTROMETRY, AMIDATION AT
RP   ASN-30, AND PYROGLUTAMATE FORMATION AT GLN-20.
RX   PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA   Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA   Schachtner J., Jacquin-Joly E., Gadenne C.;
RT   "Mating-induced differential peptidomics of neuropeptides and protein
RT   hormones in Agrotis ipsilon moths.";
RL   J. Proteome Res. 17:1397-1414(2018).
CC   -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC       physiological regulation of the heart beat.
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in corpora cardiaca (CC), corpora allata
CC       (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level).
CC       Expression in CC and CA detected in all animals, expression in AL and
CC       in GNG in some animals. {ECO:0000269|PubMed:29466015}.
CC   -!- MASS SPECTROMETRY: Mass=1369.62; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:29466015};
CC   -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKT2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0071858; F:corazonin receptor binding; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045823; P:positive regulation of heart contraction; IEA:InterPro.
DR   InterPro; IPR020190; Procorazonin.
DR   Pfam; PF17308; Corazonin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         20..30
FT                   /note="Corazonin"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444224"
FT   PROPEP          34..103
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444225"
FT   MOD_RES         20
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT   MOD_RES         30
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
SQ   SEQUENCE   103 AA;  11862 MW;  849D9EAA29B37D3F CRC64;
     MSANVTLLLI FVTLASVTAQ TFQYSRGWTN GKRDQGHLRP ELKELINNMD KILSPCQKNK
     LKYLLEGKPV TERLLIPCDI LDTEEYPRAL TERNLNAMMD AFY