CORZ_ANOGA
ID CORZ_ANOGA Reviewed; 171 AA.
AC A0NDK8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Pro-corazonin;
DE Short=Crz;
DE Contains:
DE RecName: Full=Corazonin;
DE Contains:
DE RecName: Full=Corazonin precursor-related peptide;
DE Short=CPRP;
DE Flags: Precursor;
GN Name=CRZ {ECO:0000312|EMBL:EAU76925.1}; ORFNames=AGAP003675;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1] {ECO:0000312|EMBL:EAU76925.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC physiological regulation of the heart beat (By similarity).
CC {ECO:0000250|UniProtKB:Q26377}.
CC -!- SUBCELLULAR LOCATION: [Corazonin]: Secreted
CC {ECO:0000250|UniProtKB:Q26377}.
CC -!- SUBCELLULAR LOCATION: [Corazonin precursor-related peptide]: Secreted
CC {ECO:0000250|UniProtKB:Q26377}.
CC -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
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DR EMBL; AAAB01008888; EAU76925.1; -; Genomic_DNA.
DR RefSeq; XP_001230939.1; XM_001230938.2.
DR RefSeq; XP_003436563.1; XM_003436515.1.
DR AlphaFoldDB; A0NDK8; -.
DR STRING; 7165.AGAP003675-PB; -.
DR PaxDb; A0NDK8; -.
DR GeneID; 4576842; -.
DR KEGG; aga:AgaP_AGAP003675; -.
DR CTD; 4576842; -.
DR VEuPathDB; VectorBase:AGAP003675; -.
DR eggNOG; ENOG502T8PQ; Eukaryota.
DR HOGENOM; CLU_1866778_0_0_1; -.
DR InParanoid; A0NDK8; -.
DR OrthoDB; 1626389at2759; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0071858; F:corazonin receptor binding; IEA:InterPro.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
DR InterPro; IPR020190; Procorazonin.
DR Pfam; PF17308; Corazonin; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250|UniProtKB:Q26377"
FT CHAIN 21..171
FT /note="Pro-corazonin"
FT /evidence="ECO:0000255"
FT /id="PRO_0000341606"
FT PEPTIDE 21..31
FT /note="Corazonin"
FT /id="PRO_0000341492"
FT PEPTIDE 35..79
FT /note="Corazonin precursor-related peptide"
FT /id="PRO_0000341493"
FT PROPEP 82..171
FT /evidence="ECO:0000250|UniProtKB:Q26377"
FT /id="PRO_0000341494"
FT MOD_RES 21
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:Q26377"
FT MOD_RES 31
FT /note="Asparagine amide"
FT /evidence="ECO:0000250|UniProtKB:Q26377"
SQ SEQUENCE 171 AA; 18059 MW; B8464114F38DB704 CRC64;
MLHTRTIALL LVGLVVLVNA QTFQYSRGWT NGKRSPLSSS SSSPSSSAAM EPLTANQLLA
SALSSGGLNS LKPSEKALLR RFLRNPCDLR VASLLAAAHP TKELFPLAGN SFDSAESAGA
AFVLPPFLMD PDESNGGIGG SNLANGRSME DELRFKRGTA TGFSDHRQKI A
