ID   CORZ_APIME              Reviewed;         107 AA.
AC   Q5DW47;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Pro-corazonin;
DE            Short=AmCrz;
DE            Short=Crz;
DE   Contains:
DE     RecName: Full=Corazonin;
DE   Contains:
DE     RecName: Full=Corazonin precursor-related peptide;
DE              Short=CPRP;
DE   Flags: Precursor;
GN   Name=Crz {ECO:0000250|UniProtKB:Q26377}; ORFNames=GB17245;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1] {ECO:0000312|EMBL:BAD90662.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:BAD90662.1};
RA   Roller L., Tanaka S., Kimura K., Satake H., Tanaka Y.;
RT   "Molecular cloning of [Thr4, His7]-corazonin (Apime-corazonin) and its
RT   distribution in the central nervous system of the honey bee Apis mellifera
RT   (Hymenoptera: Apidae).";
RL   Appl. Entomol. Zool. (Jpn.) 41:331-338(2006).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 22-32, PYROGLUTAMATE FORMATION AT GLN-22, AMIDATION AT
RP   ASN-32, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RX   PubMed=16406615; DOI=10.1016/j.peptides.2005.03.065;
RA   Verleyen P., Baggerman G., Mertens I., Vandersmissen T., Huybrechts J.,
RA   Van Lommel A., De Loof A., Schoofs L.;
RT   "Cloning and characterization of a third isoform of corazonin in the honey
RT   bee Apis mellifera.";
RL   Peptides 27:493-499(2006).
RN   [3] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 22-32, AND MASS SPECTROMETRY.
RC   TISSUE=Brain {ECO:0000269|PubMed:17068263};
RX   PubMed=17068263; DOI=10.1126/science.1124128;
RA   Hummon A.B., Richmond T.A., Verleyen P., Baggerman G., Huybrechts J.,
RA   Ewing M.A., Vierstraete E., Rodriguez-Zas S.L., Schoofs L., Robinson G.E.,
RA   Sweedler J.V.;
RT   "From the genome to the proteome: uncovering peptides in the Apis brain.";
RL   Science 314:647-649(2006).
CC   -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC       physiological regulation of the heart beat (By similarity).
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin]: Secreted.
CC   -!- SUBCELLULAR LOCATION: [Corazonin precursor-related peptide]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- TISSUE SPECIFICITY: In the adult brain, expressed in four neurons of
CC       the lateral protocerebrum project axons towards the retrocerebral
CC       complex. {ECO:0000269|PubMed:16406615}.
CC   -!- MASS SPECTROMETRY: [Corazonin]: Mass=1322.57; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16406615, ECO:0000269|PubMed:17068263};
CC   -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
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DR   EMBL; AB201717; BAD90662.1; -; mRNA.
DR   RefSeq; NP_001012981.1; NM_001012963.1.
DR   AlphaFoldDB; Q5DW47; -.
DR   STRING; 7460.GB53951-PA; -.
DR   PaxDb; Q5DW47; -.
DR   EnsemblMetazoa; NM_001012963; NP_001012981; GeneID_503862.
DR   GeneID; 503862; -.
DR   KEGG; ame:503862; -.
DR   CTD; 12973; -.
DR   eggNOG; ENOG502T9RC; Eukaryota.
DR   InParanoid; Q5DW47; -.
DR   OrthoDB; 1626389at2759; -.
DR   PhylomeDB; Q5DW47; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0071858; F:corazonin receptor binding; IEA:InterPro.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
DR   InterPro; IPR020190; Procorazonin.
DR   Pfam; PF17308; Corazonin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:16406615,
FT                   ECO:0000269|PubMed:17068263"
FT   CHAIN           22..107
FT                   /note="Pro-corazonin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000341607"
FT   PEPTIDE         22..32
FT                   /note="Corazonin"
FT                   /evidence="ECO:0000269|PubMed:16406615"
FT                   /id="PRO_5000052220"
FT   PEPTIDE         36..85
FT                   /note="Corazonin precursor-related peptide"
FT                   /id="PRO_0000341495"
FT   PROPEP          88..107
FT                   /evidence="ECO:0000269|PubMed:16406615"
FT                   /id="PRO_0000341496"
FT   MOD_RES         22
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:16406615"
FT   MOD_RES         32
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:16406615"
SQ   SEQUENCE   107 AA;  12305 MW;  B588CC4039BE66B7 CRC64;
     MVNSQILILF ILSLTITIVM CQTFTYSHGW TNGKRSTSLE ELANRNAIQS DNVFANCELQ
     KLRLLLQGNI NNQLFQTPCE LLNFPKRSFS ENMINDHRQP APTNNNY