ID   CORZ_BOMMO              Reviewed;         101 AA.
AC   Q86N75;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Pro-corazonin;
DE            Short=BmCrz;
DE            Short=Crz;
DE   Contains:
DE     RecName: Full=Corazonin;
DE   Contains:
DE     RecName: Full=Corazonin precursor-related peptide;
DE              Short=CPRP;
DE   Flags: Precursor;
GN   Name=crz;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1] {ECO:0000312|EMBL:BAC66443.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Roller L., Tanaka Y.;
RT   "Corazonin gene in the silkworm Bombyx mori.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC       physiological regulation of the heart beat (By similarity).
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin precursor-related peptide]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
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DR   EMBL; AB106876; BAC66443.1; -; mRNA.
DR   RefSeq; NP_001036899.1; NM_001043434.1.
DR   RefSeq; XP_012546619.1; XM_012691165.1.
DR   RefSeq; XP_012546625.1; XM_012691171.1.
DR   AlphaFoldDB; Q86N75; -.
DR   EnsemblMetazoa; BGIBMGA002280-RA; BGIBMGA002280-TA; BGIBMGA002280.
DR   GeneID; 692443; -.
DR   KEGG; bmor:692443; -.
DR   CTD; 12973; -.
DR   eggNOG; ENOG502TC0X; Eukaryota.
DR   HOGENOM; CLU_2266589_0_0_1; -.
DR   InParanoid; Q86N75; -.
DR   OMA; KILNPCQ; -.
DR   OrthoDB; 1626389at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0071858; F:corazonin receptor binding; IEA:InterPro.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
DR   InterPro; IPR020190; Procorazonin.
DR   Pfam; PF17308; Corazonin; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..101
FT                   /note="Pro-corazonin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000341608"
FT   PEPTIDE         20..30
FT                   /note="Corazonin"
FT                   /id="PRO_0000000946"
FT   PEPTIDE         34..101
FT                   /note="Corazonin precursor-related peptide"
FT                   /id="PRO_0000000947"
FT   MOD_RES         20
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT   MOD_RES         30
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   101 AA;  11931 MW;  285B67E8081446C0 CRC64;
     MVTNITLILT LMTLASVTAQ TFQYSRGWTN GKRDGHKRDE LRDEVLERIL TPCQLDKLKY
     VLEGKPLNDR LFVPCDYIEE EVNQPKRYKG ERNHELFDVF Q