CORZ_CAMFO
ID CORZ_CAMFO Reviewed; 101 AA.
AC E2ARW3;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Pro-corazonin {ECO:0000312|EMBL:EFN63812.1};
DE Contains:
DE RecName: Full=Corazonin {ECO:0000303|PubMed:25641051};
DE Flags: Precursor;
GN ORFNames=EAG_04993 {ECO:0000312|EMBL:EFN63812.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 17-27, TISSUE SPECIFICITY, MASS SPECTROMETRY,
RP IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT ASN-27.
RX PubMed=25641051; DOI=10.1021/pr5011636;
RA Schmitt F., Vanselow J.T., Schlosser A., Kahnt J., Roessler W., Wegener C.;
RT "Neuropeptidomics of the carpenter ant Camponotus floridanus.";
RL J. Proteome Res. 14:1504-1514(2015).
CC -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC physiological regulation of the heart beat.
CC {ECO:0000250|UniProtKB:P11496}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25641051}.
CC -!- TISSUE SPECIFICITY: Expressed in central brain and the retrocerebral
CC complex but not in antennal lobes, optic lobes or in gnathal, thoracic
CC and abdominal ganglia (at protein level).
CC {ECO:0000269|PubMed:25641051}.
CC -!- MASS SPECTROMETRY: [Corazonin]: Mass=1369.62; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:25641051};
CC -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL442192; EFN63812.1; -; Genomic_DNA.
DR AlphaFoldDB; E2ARW3; -.
DR STRING; 104421.E2ARW3; -.
DR InParanoid; E2ARW3; -.
DR OMA; LCQTFQY; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0071858; F:corazonin receptor binding; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045823; P:positive regulation of heart contraction; IEA:InterPro.
DR InterPro; IPR020190; Procorazonin.
DR Pfam; PF17308; Corazonin; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..101
FT /note="Pro-corazonin"
FT /evidence="ECO:0000255"
FT /id="PRO_0000434203"
FT PEPTIDE 17..27
FT /note="Corazonin"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434204"
FT PROPEP 31..101
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434205"
FT MOD_RES 27
FT /note="Asparagine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
SQ SEQUENCE 101 AA; 11587 MW; 27D57205E613C61F CRC64;
MLVLFVLSLV VSCALCQTFQ YSRGWTNGKR SNFPAEISAL GYDRFTNGEL KRLKMLIYGS
ADEQPLLIHC DFVDKLKKFA HTDNAEPDQL RREKAPNNDN Y