ID   CORZ_DELRA              Reviewed;          11 AA.
AC   B3EWM1; B3EWM2;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-JUN-2021, entry version 9.
DE   RecName: Full=Corazonin {ECO:0000303|PubMed:20869420, ECO:0000303|PubMed:22848525};
DE   Contains:
DE     RecName: Full=Corazonin(3-11) {ECO:0000303|PubMed:22848525};
OS   Delia radicum (Cabbage root fly) (Anthomyia brassicae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Anthomyiidae; Anthomyiinae; Delia.
OX   NCBI_TaxID=30064;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT
RP   ASN-11.
RC   TISSUE=Abdominal ganglion {ECO:0000269|PubMed:20869420},
RC   Brain {ECO:0000269|PubMed:20869420},
RC   Corpora allata {ECO:0000269|PubMed:20869420}, and
RC   Corpora cardiaca {ECO:0000269|PubMed:20869420};
RX   PubMed=20869420; DOI=10.1016/j.peptides.2010.08.028;
RA   Audsley N., Matthews H.J., Down R.E., Weaver R.J.;
RT   "Neuropeptides associated with the central nervous system of the cabbage
RT   root fly, Delia radicum (L).";
RL   Peptides 32:434-440(2011).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MASS
RP   SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT ASN-11.
RC   TISSUE=CNS {ECO:0000269|PubMed:22848525}, and
RC   Ring ganglion {ECO:0000269|PubMed:22848525};
RX   PubMed=22848525; DOI=10.1371/journal.pone.0041543;
RA   Zoephel J., Reiher W., Rexer K.-H., Kahnt J., Wegener C.;
RT   "Peptidomics of the agriculturally damaging larval stage of the cabbage
RT   root fly Delia radicum (Diptera: Anthomyiidae).";
RL   PLoS ONE 7:E41543-E41543(2012).
CC   -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC       physiological regulation of the heart beat (By similarity).
CC       {ECO:0000250|UniProtKB:P11496}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11496}.
CC   -!- TISSUE SPECIFICITY: In larvae, both corazonin and corazonin(3-11) are
CC       expressed in the CNS but not the midgut or thoracic perisympathetic
CC       organs (tPSO) and abdominal perisympathetic organs (aPSO). Corazonin is
CC       expressed in the ring gland (at protein level). In adults, corazonin is
CC       expressed in brain, cardiaca, corpora allata and thoracic-abdominal
CC       ganglion (at protein level). {ECO:0000269|PubMed:20869420,
CC       ECO:0000269|PubMed:22848525}.
CC   -!- DEVELOPMENTAL STAGE: Detected in larvae and adults.
CC       {ECO:0000269|PubMed:22848525}.
CC   -!- MASS SPECTROMETRY: [Corazonin]: Mass=1369.7; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- MASS SPECTROMETRY: [Corazonin]: Mass=1369.69; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- MASS SPECTROMETRY: [Corazonin(3-11)]: Mass=1157.56; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:22848525};
CC   -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..11
FT                   /note="Corazonin"
FT                   /evidence="ECO:0000269|PubMed:22848525"
FT                   /id="PRO_0000419718"
FT   PEPTIDE         3..11
FT                   /note="Corazonin(3-11)"
FT                   /evidence="ECO:0000269|PubMed:22848525"
FT                   /id="PRO_0000419719"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:22848525"
FT   MOD_RES         11
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:20869420,
FT                   ECO:0000269|PubMed:22848525"
FT   CONFLICT        1
FT                   /note="Q -> E (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   11 AA;  1387 MW;  C7CFF32D6415AB46 CRC64;
     QTFQYSRGWT N