ID   CORZ_DROPS              Reviewed;         161 AA.
AC   Q299B0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Pro-corazonin;
DE            Short=Crz;
DE            Short=Dp-Crz;
DE   Contains:
DE     RecName: Full=Corazonin;
DE   Contains:
DE     RecName: Full=Corazonin precursor-related peptide;
DE              Short=CPRP;
DE   Flags: Precursor;
GN   Name=Crz {ECO:0000250|UniProtKB:Q26377}; ORFNames=GA17242;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL27793.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC       physiological regulation of the heart beat. Clock (Clk) and cycle (cyc)
CC       proteins negatively regulate Crz transcription in a cell-specific
CC       manner (By similarity). {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin precursor-related peptide]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL27793.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM000070; EAL27793.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001358652.1; XM_001358615.3.
DR   AlphaFoldDB; Q299B0; -.
DR   STRING; 7237.FBpp0283881; -.
DR   EnsemblMetazoa; FBtr0285443; FBpp0283881; FBgn0077255.
DR   GeneID; 4801582; -.
DR   KEGG; dpo:Dpse_GA17242; -.
DR   eggNOG; ENOG502T821; Eukaryota.
DR   HOGENOM; CLU_1679760_0_0_1; -.
DR   InParanoid; Q299B0; -.
DR   OMA; RHRQSNE; -.
DR   PhylomeDB; Q299B0; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0077255; Expressed in insect adult head.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IEA:EnsemblMetazoa.
DR   GO; GO:0071858; F:corazonin receptor binding; IEA:EnsemblMetazoa.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0006117; P:acetaldehyde metabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0048149; P:behavioral response to ethanol; IEA:EnsemblMetazoa.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:EnsemblMetazoa.
DR   GO; GO:0007619; P:courtship behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
DR   InterPro; IPR020190; Procorazonin.
DR   Pfam; PF17308; Corazonin; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT   CHAIN           21..161
FT                   /note="Pro-corazonin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000341611"
FT   PEPTIDE         21..31
FT                   /note="Corazonin"
FT                   /id="PRO_0000341500"
FT   PEPTIDE         35..67
FT                   /note="Corazonin precursor-related peptide"
FT                   /id="PRO_0000341501"
FT   PROPEP          70..161
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT                   /id="PRO_0000341502"
FT   REGION          93..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         21
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT   MOD_RES         31
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
SQ   SEQUENCE   161 AA;  17786 MW;  AF04402AA2EECE37 CRC64;
     MMRLLLLPLF LFTLSMACMG QTFQYSRGWT NGKRALTPPS LLSHGHFNRA SDLGFSDLYD
     VQDWSSERRL ERCLAQLQRS LLSRVYGSVV DFNANRPEPD SSDSGSSRNR ANNNNENVLY
     PTPIQNRHHS SNELLEEISA AVAGSGPTGA GSGEPSVFGK H