ID   CORZ_DROSI              Reviewed;         154 AA.
AC   Q5W1L5; B4QZW4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Pro-corazonin;
DE            Short=Crz;
DE            Short=Ds-Crz;
DE   Contains:
DE     RecName: Full=Corazonin;
DE   Contains:
DE     RecName: Full=Corazonin precursor-related peptide;
DE              Short=CPRP;
DE   Flags: Precursor;
GN   Name=Crz; ORFNames=GD18955;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:CAH65472.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Head {ECO:0000269|PubMed:15669053};
RX   PubMed=15669053; DOI=10.1002/cne.20419;
RA   Choi Y.J., Lee G., Hall J.C., Park J.H.;
RT   "Comparative analysis of Corazonin-encoding genes (Crz's) in Drosophila
RT   species and functional insights into Crz-expressing neurons.";
RL   J. Comp. Neurol. 482:372-385(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC       physiological regulation of the heart beat. Clock (Clk) and cycle (cyc)
CC       proteins negatively regulate Crz transcription in a cell-specific
CC       manner (By similarity). {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin precursor-related peptide]: Secreted
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- TISSUE SPECIFICITY: Expression is restricted to 24 neurons in the
CC       larval CNS (8 in the brain and 16 in the ventral nerve cord) and 12-16
CC       neurons in the pars lateralis of the adult brain.
CC       {ECO:0000269|PubMed:15669053}.
CC   -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
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DR   EMBL; AJ851891; CAH65472.1; -; Genomic_DNA.
DR   EMBL; CM000364; EDX12962.1; -; Genomic_DNA.
DR   RefSeq; XP_002103459.1; XM_002103423.2.
DR   AlphaFoldDB; Q5W1L5; -.
DR   STRING; 7240.Q5W1L5; -.
DR   EnsemblMetazoa; FBtr0218865; FBpp0217357; FBgn0064364.
DR   GeneID; 6728108; -.
DR   HOGENOM; CLU_1679760_0_0_1; -.
DR   OMA; RHRQSNE; -.
DR   PhylomeDB; Q5W1L5; -.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0064364; Expressed in embryo and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IEA:EnsemblMetazoa.
DR   GO; GO:0071858; F:corazonin receptor binding; IEA:EnsemblMetazoa.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0006117; P:acetaldehyde metabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0048149; P:behavioral response to ethanol; IEA:EnsemblMetazoa.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:EnsemblMetazoa.
DR   GO; GO:0007619; P:courtship behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
DR   InterPro; IPR020190; Procorazonin.
DR   Pfam; PF17308; Corazonin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT   CHAIN           20..154
FT                   /note="Pro-corazonin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000341612"
FT   PEPTIDE         20..30
FT                   /note="Corazonin"
FT                   /id="PRO_0000341503"
FT   PEPTIDE         34..67
FT                   /note="Corazonin precursor-related peptide"
FT                   /id="PRO_0000341504"
FT   PROPEP          70..154
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT                   /id="PRO_0000341505"
FT   MOD_RES         20
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT   MOD_RES         30
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
SQ   SEQUENCE   154 AA;  17194 MW;  01FD3BEF0E3DFA51 CRC64;
     MLRLLLLPLF LFTLSMCMGQ TFQYSRGWTN GKRSFNAASP LLANGHLHRG SELGLTDLYD
     LQDWSSDRRL ERCLSQLQRS LIARNCVPGS DFNANRVDPD PENSVHPRLS NINGENVLYS
     SANIPNRHRQ SNELLEELSA AGGASAEPNV FGKH