ID   CORZ_GALME              Reviewed;         113 AA.
AC   Q9GSA4;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Pro-corazonin;
DE            Short=Crz;
DE   Contains:
DE     RecName: Full=Corazonin;
DE   Contains:
DE     RecName: Full=Corazonin precursor-related peptide;
DE              Short=CPRP;
DE   Flags: Precursor;
GN   Name=crz {ECO:0000312|EMBL:AAF87082.1};
OS   Galleria mellonella (Greater wax moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea;
OC   Pyralidae; Galleriinae; Galleria.
OX   NCBI_TaxID=7137;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAF87082.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-30, TISSUE SPECIFICITY,
RP   AND AMIDATION AT ASN-30.
RC   TISSUE=Brain {ECO:0000312|EMBL:AAF87082.1};
RX   PubMed=11520357; DOI=10.1046/j.0962-1075.2001.00272.x;
RA   Hansen I.A., Sehnal F., Meyer S.R., Scheller K.;
RT   "Corazonin gene expression in the waxmoth Galleria mellonella.";
RL   Insect Mol. Biol. 10:341-346(2001).
CC   -!- FUNCTION: Cardioactive peptide. Corazonin is probably involved in the
CC       physiological regulation of the heart beat (By similarity).
CC       {ECO:0000250|UniProtKB:Q26377}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin]: Secreted
CC       {ECO:0000269|PubMed:11520357}.
CC   -!- SUBCELLULAR LOCATION: [Corazonin precursor-related peptide]: Secreted
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Four pairs of lateral neurosecretory cells in the
CC       brains of late instar larvae, pupae and adults.
CC       {ECO:0000269|PubMed:11520357}.
CC   -!- SIMILARITY: Belongs to the corazonin family. {ECO:0000305}.
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DR   EMBL; AY004866; AAF87082.1; -; mRNA.
DR   AlphaFoldDB; Q9GSA4; -.
DR   Proteomes; UP000504614; Unplaced.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0071858; F:corazonin receptor binding; IEA:InterPro.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
DR   InterPro; IPR020190; Procorazonin.
DR   Pfam; PF17308; Corazonin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:11520357"
FT   CHAIN           20..113
FT                   /note="Pro-corazonin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000341614"
FT   PEPTIDE         20..30
FT                   /note="Corazonin"
FT                   /evidence="ECO:0000269|PubMed:11520357"
FT                   /id="PRO_0000000951"
FT   PEPTIDE         34..113
FT                   /note="Corazonin precursor-related peptide"
FT                   /id="PRO_0000000952"
FT   REGION          74..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         20
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:Q26377"
FT   MOD_RES         30
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:11520357"
SQ   SEQUENCE   113 AA;  12766 MW;  0E62988AA231CA28 CRC64;
     MATNITMFLI VITLTSVAAQ TFQYSRGWTN GKRDGHKTED IRDLTNNLER ILSPCQMNKL
     KYVLEGKPLN ERLLGPCDTS KTRSTTNPSD TNTSAVKTPC STHFNKHCYS FSY