COS10_YEAST
ID COS10_YEAST Reviewed; 374 AA.
AC P52924; D6W1Q0;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein COS10;
GN Name=COS10; OrderedLocusNames=YNR075W; ORFNames=N3820;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8904342;
RX DOI=10.1002/(sici)1097-0061(19960315)12:3<289::aid-yea909>3.0.co;2-m;
RA Levesque H., Lepingle A., Nicaud J.-M., Gaillardin C.;
RT "Sequencing of a 9.2 kb telomeric fragment from the right arm of
RT Saccharomyces cerevisiae chromosome XIV.";
RL Yeast 12:289-295(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Present with 2370 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the DUP/COS family. {ECO:0000305}.
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DR EMBL; X86790; CAA60488.1; -; Genomic_DNA.
DR EMBL; Z71690; CAA96359.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10616.1; -; Genomic_DNA.
DR PIR; S54057; S54057.
DR RefSeq; NP_014473.1; NM_001183252.1.
DR AlphaFoldDB; P52924; -.
DR BioGRID; 35901; 26.
DR DIP; DIP-4249N; -.
DR IntAct; P52924; 1.
DR STRING; 4932.YNR075W; -.
DR PaxDb; P52924; -.
DR PRIDE; P52924; -.
DR EnsemblFungi; YNR075W_mRNA; YNR075W; YNR075W.
DR GeneID; 855812; -.
DR KEGG; sce:YNR075W; -.
DR SGD; S000005358; COS10.
DR VEuPathDB; FungiDB:YNR075W; -.
DR eggNOG; ENOG502SAGH; Eukaryota.
DR GeneTree; ENSGT00940000176283; -.
DR HOGENOM; CLU_062892_1_0_1; -.
DR InParanoid; P52924; -.
DR OMA; GMASTWF; -.
DR BioCyc; YEAST:G3O-33379-MON; -.
DR PRO; PR:P52924; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P52924; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005768; C:endosome; ISS:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; HDA:SGD.
DR GO; GO:0006897; P:endocytosis; IMP:SGD.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:SGD.
DR InterPro; IPR001142; DUP/COS.
DR Pfam; PF00674; DUP; 2.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..374
FT /note="Protein COS10"
FT /id="PRO_0000207521"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..374
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 374 AA; 43867 MW; 7A7195A782065B5F CRC64;
MGEEIRLLSS KGLETHSSFC LPEDIFRNRL TWLCSEIRNS GFWIWSLSWL PLAVWWGMAS
TWFYPLLTSV VLILALIAIL PVVQIQYSKY TLSNQLTQLS KEIIKSAPGA YSADWDAVAI
HFNSYLYENK AWKTAHFFFN GTDCQEAFRK TILEPAVLRR QNEDPRFSSI EILVPYTEDA
VQVYFTKVNA QWRLIHGKKE CKLTMLENVK LPKETYRCKL AWSCQRIRIS FSPLDFLPDM
SDFFICANLS PACLVSYWLI DIFFRMIDDF QNIRPKSMKV DDKMQYLSDI INEQGASPEK
WDTIARKTNT RLFEKRVWKN EEFFFDGTDC QAFFERNFSS LLFSKKSASP RSLNVELWKY
IQEAQLSCNY EPLP
