COS12_YEAST
ID COS12_YEAST Reviewed; 380 AA.
AC P53053; D6VV71;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein COS12;
GN Name=COS12; OrderedLocusNames=YGL263W; ORFNames=NRC380;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8972578;
RX DOI=10.1002/(sici)1097-0061(199612)12:15<1555::aid-yea43>3.0.co;2-q;
RA Coissac E., Maillier E., Robineau S., Netter P.;
RT "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome
RT VII of Saccharomyces cerevisiae.";
RL Yeast 12:1555-1562(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the DUP/COS family. {ECO:0000305}.
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DR EMBL; X94357; CAA64124.1; -; Genomic_DNA.
DR EMBL; Z72785; CAA96983.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07855.1; -; Genomic_DNA.
DR PIR; S61598; S61598.
DR RefSeq; NP_011251.1; NM_001181129.1.
DR AlphaFoldDB; P53053; -.
DR BioGRID; 33016; 25.
DR DIP; DIP-5034N; -.
DR IntAct; P53053; 2.
DR MINT; P53053; -.
DR STRING; 4932.YGL263W; -.
DR PaxDb; P53053; -.
DR PRIDE; P53053; -.
DR EnsemblFungi; YGL263W_mRNA; YGL263W; YGL263W.
DR GeneID; 852628; -.
DR KEGG; sce:YGL263W; -.
DR SGD; S000003232; COS12.
DR VEuPathDB; FungiDB:YGL263W; -.
DR eggNOG; ENOG502SAGH; Eukaryota.
DR GeneTree; ENSGT00940000176283; -.
DR HOGENOM; CLU_062892_1_0_1; -.
DR InParanoid; P53053; -.
DR OMA; KWHWINS; -.
DR BioCyc; YEAST:G3O-30731-MON; -.
DR PRO; PR:P53053; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53053; protein.
DR GO; GO:0005768; C:endosome; ISS:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:SGD.
DR InterPro; IPR001142; DUP/COS.
DR Pfam; PF00674; DUP; 2.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..380
FT /note="Protein COS12"
FT /id="PRO_0000207522"
FT TOPO_DOM 1..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..231
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 380 AA; 44804 MW; 52F58F4E400CA596 CRC64;
MDGAKFENTV AFLPSEIFDC YNSTLPKNVF RSFVTWSCYE KFNSLEFRTW LLMWLPLIIA
WKIRGKRHYL VIVTALMFEV LYFLWTYSYI FRERTLGKQV SQFAKEIITN TPGIDTEDWE
RVAVNFNSYL YENKLWNTEY FFFDGSSCQE AFRKMLLEPF SLKKNDFANA KVPDGSVCYT
EKALQVYFTQ IERKWHWINS EGFLHNKTTQ SVQFSKHGYG SKLLWAFKEV TIMNSRFAFF
SIAYLNGLLT IPRLRNSLHI LYVCAVLSSM IIEYLIGIDK FRFKSMNLIH KLQFLSYITC
GHEKSDATNW SQIAKRTNTY MFEQKIWNSP ILFSDGIDCE KFFKWYFSTP VSSQASLSVG
STDFELWPYI KEAQSACNDV
