COS2_YEAST
ID COS2_YEAST Reviewed; 379 AA.
AC P0CX12; D6VQU7; P38363;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Protein COS2;
GN Name=COS2; OrderedLocusNames=YBR302C; ORFNames=YBR2121;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the DUP/COS family. {ECO:0000305}.
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DR EMBL; Z36171; CAA85267.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07417.1; -; Genomic_DNA.
DR PIR; S46187; S46187.
DR RefSeq; NP_009861.1; NM_001178650.1.
DR RefSeq; NP_013574.1; NM_001182495.1.
DR AlphaFoldDB; P0CX12; -.
DR BioGRID; 32994; 1.
DR BioGRID; 35073; 12.
DR STRING; 4932.YBR302C; -.
DR iPTMnet; P0CX12; -.
DR MaxQB; P0CX12; -.
DR PaxDb; P0CX12; -.
DR PRIDE; P0CX12; -.
DR EnsemblFungi; YBR302C_mRNA; YBR302C; YBR302C.
DR EnsemblFungi; YML132W_mRNA; YML132W; YML132W.
DR GeneID; 852605; -.
DR GeneID; 854907; -.
DR KEGG; sce:YBR302C; -.
DR KEGG; sce:YML132W; -.
DR SGD; S000000506; COS2.
DR VEuPathDB; FungiDB:YBR302C; -.
DR VEuPathDB; FungiDB:YML132W; -.
DR eggNOG; ENOG502SAGH; Eukaryota.
DR HOGENOM; CLU_062892_1_0_1; -.
DR InParanoid; P0CX12; -.
DR OMA; MWPLPLN; -.
DR BioCyc; YEAST:G3O-29218-MON; -.
DR PRO; PR:P0CX12; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P0CX12; protein.
DR ExpressionAtlas; P0CX12; baseline.
DR GO; GO:0005768; C:endosome; IDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:SGD.
DR InterPro; IPR001142; DUP/COS.
DR Pfam; PF00674; DUP; 2.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..379
FT /note="Protein COS2"
FT /id="PRO_0000207514"
FT TOPO_DOM 1..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..254
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 379 AA; 45165 MW; 2AAB51B6C103AF61 CRC64;
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS
VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS KQLIQFCKEI TENTPSSDPH
DWEVVAANLN SYLYENNVWN TKYFFFNAMV CQEAFRTTLL EPFSLKKDKA AKVKSFKDSV
PYIEEALGVY FTEVEKQWKL FNTEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI
PFLNFLCCIY VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE
SGANGWDEIA RKMNRYLFEK KAWKNEEFFF DGIDCEWFFN HFFYRVLSAK KSMWPLPLNV
ELWPYIKEAQ LSRSEVLLV
