COS4_YEAST
ID COS4_YEAST Reviewed; 379 AA.
AC P43542; D6VTG8;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein COS4;
GN Name=COS4; OrderedLocusNames=YFL062W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DUP/COS family. {ECO:0000305}.
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DR EMBL; D50617; BAA09179.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12378.1; -; Genomic_DNA.
DR PIR; S56193; S56193.
DR RefSeq; NP_116593.1; NM_001179905.1.
DR AlphaFoldDB; P43542; -.
DR BioGRID; 31085; 28.
DR DIP; DIP-7524N; -.
DR IntAct; P43542; 25.
DR MINT; P43542; -.
DR STRING; 4932.YFL062W; -.
DR iPTMnet; P43542; -.
DR MaxQB; P43542; -.
DR PaxDb; P43542; -.
DR PRIDE; P43542; -.
DR EnsemblFungi; YFL062W_mRNA; YFL062W; YFL062W.
DR GeneID; 850482; -.
DR KEGG; sce:YFL062W; -.
DR SGD; S000001832; COS4.
DR VEuPathDB; FungiDB:YFL062W; -.
DR eggNOG; ENOG502SAGH; Eukaryota.
DR GeneTree; ENSGT00940000176283; -.
DR HOGENOM; CLU_062892_1_0_1; -.
DR InParanoid; P43542; -.
DR OMA; EANATHF; -.
DR BioCyc; YEAST:G3O-30405-MON; -.
DR PRO; PR:P43542; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43542; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005768; C:endosome; IDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:SGD.
DR InterPro; IPR001142; DUP/COS.
DR Pfam; PF00674; DUP; 2.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..379
FT /note="Protein COS4"
FT /id="PRO_0000207515"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 379 AA; 45312 MW; 6822561BC9890275 CRC64;
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS
VWWKLSNNWI YPLMVSLLVL FWGPVFVLVI FRLSRKRSLS KQLTQFCKEI TKSTPSSDPH
DWEVVAANLN SYLYENKAWN IRYFFFNAMG CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV
PYIEEALGVY FREVEKQWKL FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI
PFLNFLCCIY VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE
SGANGWDEIA RKMNRYLFEK KVWKNEEFFF DGIDCEWFFS HFFYRVLSAK KSMRALSLNV
ELWPYIKEAQ LSCSEESLA
