ID   COS9_YEAST              Reviewed;         407 AA.
AC   P36034; D6VWY4;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Protein COS9;
GN   Name=COS9; OrderedLocusNames=YKL219W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7941750; DOI=10.1002/yea.320100511;
RA   Tzermia M., Horaitis O., Alexandraki D.;
RT   "The complete sequencing of a 24.6 kb segment of yeast chromosome XI
RT   identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open
RT   reading frames including homologues to the threonine dehydratases, membrane
RT   transporters, hydantoinases and the phospholipase A2-activating protein.";
RL   Yeast 10:663-679(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8196765; DOI=10.1038/369371a0;
RA   Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA   Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA   Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA   Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA   Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA   Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA   Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA   Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA   Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA   Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA   Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA   Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA   Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA   Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA   Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA   Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA   Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA   Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA   Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA   van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA   von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA   Becker I., Mewes H.-W.;
RT   "Complete DNA sequence of yeast chromosome XI.";
RL   Nature 369:371-378(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DUP/COS family. {ECO:0000305}.
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DR   EMBL; X75951; CAA53554.1; -; Genomic_DNA.
DR   EMBL; Z28219; CAA82064.1; -; Genomic_DNA.
DR   EMBL; BK006944; DAA08950.1; -; Genomic_DNA.
DR   PIR; S38062; S38062.
DR   RefSeq; NP_012703.1; NM_001179784.1.
DR   AlphaFoldDB; P36034; -.
DR   BioGRID; 33946; 5.
DR   DIP; DIP-7808N; -.
DR   IntAct; P36034; 1.
DR   STRING; 4932.YKL219W; -.
DR   MaxQB; P36034; -.
DR   PaxDb; P36034; -.
DR   PRIDE; P36034; -.
DR   EnsemblFungi; YKL219W_mRNA; YKL219W; YKL219W.
DR   GeneID; 853661; -.
DR   KEGG; sce:YKL219W; -.
DR   SGD; S000001702; COS9.
DR   VEuPathDB; FungiDB:YKL219W; -.
DR   eggNOG; ENOG502SAGH; Eukaryota.
DR   GeneTree; ENSGT00940000176283; -.
DR   HOGENOM; CLU_062892_1_0_1; -.
DR   InParanoid; P36034; -.
DR   OMA; AWNTEYF; -.
DR   BioCyc; YEAST:G3O-31975-MON; -.
DR   PRO; PR:P36034; -.
DR   Proteomes; UP000002311; Chromosome XI.
DR   RNAct; P36034; protein.
DR   GO; GO:0005768; C:endosome; ISS:SGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:SGD.
DR   InterPro; IPR001142; DUP/COS.
DR   Pfam; PF00674; DUP; 2.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..407
FT                   /note="Protein COS9"
FT                   /id="PRO_0000207520"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   407 AA;  48545 MW;  01142E58AAE0E758 CRC64;
     MQIVRSCNSN NKPLIPSSNW HIAIRMRGDG VKDRSIDVLS LKHFESQKVV LPQDLFMDNF
     TWMFYEFFKC FTFRTWLLLL LLMWLPGFLS QIKSINRIFP FKLCILVSCL VGIFLPNIYS
     FSHKSVLTNQ LTQFSKEIVE HAPGTDTHDW ETVAANLNSY FYENKAWNTE YFFFNAAECQ
     KAFRKVLLEP FSVKKDESSK IKSFGDSVPY IEEALQVYST EFDKKWKLFN TEKVWSPDNL
     EHVQLPKKTY RYKFTWVLKR IFNLWLFPAF ILFLACIYVS WDKGHLFRIL CCGGGFLLMV
     RVFQNMRPFS MHMEDKMQFL STIINEQESG ANGWDEIAKK MNRYLFEKKV WTSEEFFFDG
     IDCEWFFNHF FYRLLSTKKP MFDRPLNVEL WPYIKEAQLT RKQAPPV