ID   COSA_DICDI              Reviewed;          82 AA.
AC   Q558Y7;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Protein costars;
GN   Name=cosA; ORFNames=DDB_G0272861;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AX4;
RX   PubMed=15010511; DOI=10.1093/nar/gkh262;
RA   Urushihara H., Morio T., Saito T., Kohara Y., Koriki E., Ochiai H.,
RA   Maeda M., Williams J.G., Takeuchi I., Tanaka Y.;
RT   "Analyses of cDNAs from growth and slug stages of Dictyostelium
RT   discoideum.";
RL   Nucleic Acids Res. 32:1647-1653(2004).
RN   [4]
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=20940261; DOI=10.1242/jcs.064709;
RA   Pang T.L., Chen F.C., Weng Y.L., Liao H.C., Yi Y.H., Ho C.L., Lin C.H.,
RA   Chen M.Y.;
RT   "cosA, a Dictyostelium protein similar to the C-terminal domain of STARS,
RT   regulates the actin cytoskeleton and motility.";
RL   J. Cell Sci. 123:3745-3755(2010).
CC   -!- FUNCTION: Modulates actin dynamics and cell motility.
CC       {ECO:0000269|PubMed:20940261}.
CC   -!- DEVELOPMENTAL STAGE: Expression peaks at early stages of development at
CC       the time cells become highly chemotactic and aggregation competent.
CC       {ECO:0000269|PubMed:20940261}.
CC   -!- DISRUPTION PHENOTYPE: Cells form smooth plaques on bacterial lawns,
CC       produce abnormally small fruiting bodies and display reduced migration
CC       towards the cAMP source in chemotactic assays. Analysis of cell motion
CC       in cAMP gradients reveals decreased speed suggesting a defect in the
CC       cellular machinery for motility. Cells exhibit changes in the actin
CC       cytoskeleton, showing aberrant distribution of F-actin in fluorescence
CC       cell staining and an increased amount of cytoskeleton associated actin.
CC       There is also excessive pseudopod formation. Expressing cosA or it's
CC       human counterpart restores wild-type like cAMP chemotaxis response.
CC       {ECO:0000269|PubMed:20940261}.
CC   -!- SIMILARITY: Belongs to the costars family. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71068.1; -; Genomic_DNA.
DR   EMBL; AU268927; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_644929.1; XM_639837.1.
DR   AlphaFoldDB; Q558Y7; -.
DR   SMR; Q558Y7; -.
DR   STRING; 44689.DDB0202716; -.
DR   PaxDb; Q558Y7; -.
DR   EnsemblProtists; EAL71068; EAL71068; DDB_G0272861.
DR   GeneID; 8618608; -.
DR   KEGG; ddi:DDB_G0272861; -.
DR   dictyBase; DDB_G0272861; cosA.
DR   eggNOG; KOG3376; Eukaryota.
DR   HOGENOM; CLU_173478_0_0_1; -.
DR   InParanoid; Q558Y7; -.
DR   OMA; QRVHDNV; -.
DR   PhylomeDB; Q558Y7; -.
DR   PRO; PR:Q558Y7; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0031143; C:pseudopodium; IDA:dictyBase.
DR   GO; GO:0032970; P:regulation of actin filament-based process; IDA:UniProtKB.
DR   GO; GO:2000145; P:regulation of cell motility; IDA:UniProtKB.
DR   GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR   Gene3D; 1.10.10.1540; -; 1.
DR   InterPro; IPR044302; Costars.
DR   InterPro; IPR027817; Costars_dom.
DR   InterPro; IPR038095; Costars_sf.
DR   PANTHER; PTHR46334; PTHR46334; 1.
DR   Pfam; PF14705; Costars; 1.
DR   SMART; SM01283; Costars; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..82
FT                   /note="Protein costars"
FT                   /id="PRO_0000365543"
SQ   SEQUENCE   82 AA;  9209 MW;  F789435E2CDD0CD3 CRC64;
     MDVDHEVKEL VKFIKKLGTK GADGKYSVKY GVLFNDDDVA NFFEALVGTL KAAKKRGIIT
     FQGEILLQRV HDNVDVILLK DE