ID   COSB_HALS3              Reviewed;         334 AA.
AC   B0R6A8; F2Z6F0;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Chemotactic signal transduction system substrate-binding protein CosB;
DE   AltName: Full=Compatible solute binding protein;
DE   Flags: Precursor;
GN   Name=cosB; OrderedLocusNames=OE_3476R;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN CHEMOTAXIS, SUBCELLULAR
RP   LOCATION, AND GENE NAME.
RC   STRAIN=R1 / S9;
RX   PubMed=12006484; DOI=10.1093/emboj/21.10.2312;
RA   Kokoeva M.V., Storch K.F., Klein C., Oesterhelt D.;
RT   "A novel mode of sensory transduction in archaea: binding protein-mediated
RT   chemotaxis towards osmoprotectants and amino acids.";
RL   EMBO J. 21:2312-2322(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
CC   -!- FUNCTION: Mediates chemotaxis towards compatible osmolytes. May
CC       function as a receptor that binds the osmolytes and transduces a signal
CC       to CosT. Has probably no additional role in transport.
CC       {ECO:0000269|PubMed:12006484}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:12006484};
CC       Peripheral membrane protein {ECO:0000305|PubMed:12006484};
CC       Extracellular side {ECO:0000305|PubMed:12006484}. Note=Probably
CC       anchored to the membrane by lipids.
CC   -!- SIMILARITY: Belongs to the OsmX family. {ECO:0000305}.
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DR   EMBL; AJ438169; CAD27275.1; -; Genomic_DNA.
DR   EMBL; AM774415; CAP14277.1; -; Genomic_DNA.
DR   PIR; G84327; G84327.
DR   RefSeq; WP_010903285.1; NZ_CP038631.1.
DR   AlphaFoldDB; B0R6A8; -.
DR   SMR; B0R6A8; -.
DR   EnsemblBacteria; CAP14277; CAP14277; OE_3476R.
DR   GeneID; 39855650; -.
DR   GeneID; 5953659; -.
DR   KEGG; hsl:OE_3476R; -.
DR   HOGENOM; CLU_830558_0_0_2; -.
DR   OMA; KDPAWKN; -.
DR   PhylomeDB; B0R6A8; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   InterPro; IPR007210; ABC_Gly_betaine_transp_sub-bd.
DR   Pfam; PF04069; OpuAC; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Membrane; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..334
FT                   /note="Chemotactic signal transduction system substrate-
FT                   binding protein CosB"
FT                   /id="PRO_0000428988"
SQ   SEQUENCE   334 AA;  35622 MW;  5B8714DD0C77AD93 CRC64;
     MMDTPEHAST SSRRQLLGML AAGGTTAVAG CTTITGGGDT TSTGGGDSGS SSIVVGSKGY
     GEQVTLGYVA YELLANTTNA TLVDETGFGG NAAISEAYRT GNVHAYYDYM GSLWSSHPPK
     HDSADFDTPD AQYDALKSEM ESEHPIRILD RADWQNTWAV FVAERAVEGT GIQSISDLAA
     HVNSRNYDIR PAFGDGFRSR SDGLDALLDY YEFDPERVTA WASEREFLET ASAQAAGTAV
     DEGYADLGVG YSTSAWLTDV DSVRVLDDDR NFWPFFHPVG VVHEDVATDA VVAALNTMPD
     AIPDAETMQA LNSRAAASGN QQAAADHLQN NDFI