COST_HALSA
ID COST_HALSA Reviewed; 810 AA.
AC Q9HP84; Q48317;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Transducer protein CosT;
DE AltName: Full=Compatible solute transducer protein;
DE AltName: Full=HTP IV;
GN Name=cosT; Synonyms=htpIV, htr5; OrderedLocusNames=VNG_1760G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R1 / S9;
RX PubMed=8674984; DOI=10.1111/j.1574-6968.1996.tb08197.x;
RA Rudolph J., Nordmann B., Storch K.F., Gruenberg H., Rodewald K.,
RA Oesterhelt D.;
RT "A family of halobacterial transducer proteins.";
RL FEMS Microbiol. Lett. 139:161-168(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: Mediates chemotaxis towards compatible osmolytes. Probably
CC transduces the signal from the substrate-binding protein CosB to the
CC histidine kinase CheA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: Methylated by CheR. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000305}.
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DR EMBL; X95589; CAA64841.1; -; Genomic_DNA.
DR EMBL; AE004437; AAG19986.1; -; Genomic_DNA.
DR PIR; F84327; F84327.
DR PIR; T46810; T46810.
DR RefSeq; WP_010903284.1; NC_002607.1.
DR AlphaFoldDB; Q9HP84; -.
DR SMR; Q9HP84; -.
DR STRING; 64091.VNG_1760G; -.
DR PaxDb; Q9HP84; -.
DR EnsemblBacteria; AAG19986; AAG19986; VNG_1760G.
DR GeneID; 5953905; -.
DR KEGG; hal:VNG_1760G; -.
DR PATRIC; fig|64091.14.peg.1341; -.
DR HOGENOM; CLU_000445_107_19_2; -.
DR InParanoid; Q9HP84; -.
DR OMA; WERTIVD; -.
DR OrthoDB; 10018at2157; -.
DR PhylomeDB; Q9HP84; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR SMART; SM00304; HAMP; 3.
DR SMART; SM00283; MA; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 2.
PE 3: Inferred from homology;
KW Cell membrane; Chemotaxis; Membrane; Methylation; Reference proteome;
KW Repeat; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..810
FT /note="Transducer protein CosT"
FT /id="PRO_0000110551"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..323
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..810
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 345..397
FT /note="HAMP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 439..493
FT /note="HAMP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 512..748
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT REGION 403..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 556
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
FT MOD_RES 739
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
FT CONFLICT 19
FT /note="A -> G (in Ref. 1; CAA64841)"
FT /evidence="ECO:0000305"
FT CONFLICT 592
FT /note="T -> S (in Ref. 1; CAA64841)"
FT /evidence="ECO:0000305"
FT CONFLICT 735
FT /note="A -> S (in Ref. 1; CAA64841)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 810 AA; 85219 MW; 4BF36E4B7D22BD80 CRC64;
MSEPTADAGD NSPSSTDTAP LDRVKAIALL PLRSYLVKFA VALLVILVII AAGGFWVQAD
ATATLEANTE QQLEQEAVSD ATEIGDWLER NEQSVLIASN NPRLGFNTTA ADKQAYVTQL
VAAELDADRI ADVHVADPTV GGASDARIVA STDEDARGTR VSADTHPWVD RTRSIGRDTV
VSTNPYRTAG GQRVVSSMSV AADLTHVLVV EYTAGDLSDQ FGAGIDGTFT QVVRPTSDAT
AVLFSDAGTD AVGQPYIPDR SQSEIPALDS ATEQGQFTNT PTKDSVLDRE YVAAYTTVPG
KNWVVVKHAP SESAFALSNQ IRTGILGFIL VALVGVVLVG GTIGRNTAAA VQSLSAAAAE
IEAGNYDVDV ASSRRDEIGQ LFASIGSMRD ALVTQIDEAE AAREQATEAQ QDAEAERERA
EDARERAEDA KADAEALAAE LEAQAERYSD VMAACADGDL TRRMPADDTD NEAMAAIAAS
FNEMLAQWEH TIIDIQEFAD AVATASEEAE VGAADAERAS GQVSESVQEI AGAADEQRNM
LDTVSGEMTD LSAAIEEVAA SADSVAEHSH QTAEIARDGE QTAEDAIERS LTVQEAIDAT
VQNVEALDDQ MAEISEIVDL ISDIAEQTNM LALNANIEAA RADKSGDGFA VVADEVKDLA
EETQESAGDI ERRITEVQSQ TTATVAEARA AEESMDAGID AVEEVVDAFT AVSDHADETD
TGVQEISDTT DDQAASTEEA VSMTEEVADL SDSTAGEAQS VSAAAEEQAA SMSEISDSVE
SLSGQAEQLK ALLSEFEVDA DRDVTPTQTD
