COT1_MOUSE
ID COT1_MOUSE Reviewed; 422 AA.
AC Q60632; Q61438;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=COUP transcription factor 1;
DE Short=COUP-TF1;
DE AltName: Full=COUP transcription factor I;
DE Short=COUP-TF I;
DE AltName: Full=Nuclear receptor subfamily 2 group F member 1;
DE AltName: Full=V-erbA-related protein 3;
DE Short=EAR-3;
GN Name=Nr2f1; Synonyms=Erbal3, Tfcoup1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=8183930; DOI=10.1073/pnas.91.10.4451;
RA Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.;
RT "Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-
RT transcription factors in the developing mouse central nervous system:
RT evidence for a role in segmental patterning of the diencephalon.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7947324; DOI=10.1016/0925-4773(94)90098-1;
RA Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S., Vervaart J.M.A.,
RA Schoorlemmer J., Kruijer W.;
RT "Cloning and expression during development of three murine members of the
RT COUP family of nuclear orphan receptors.";
RL Mech. Dev. 47:81-97(1994).
CC -!- FUNCTION: Coup (chicken ovalbumin upstream promoter) transcription
CC factor binds to the ovalbumin promoter and, in conjunction with another
CC protein (S300-II) stimulates initiation of transcription. Binds to both
CC direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses
CC transcriptional activity of LHCG (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as dimer; homodimer and probable heterodimer with
CC NR2F6. Interacts with GTF2B; this interaction is direct. Interacts with
CC COPS2. {ECO:0000250|UniProtKB:P10589}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expression begins in 8.5-day-old embryos, peaks at
CC 14-15 days and declines before birth.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000305}.
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DR EMBL; U07625; AAA19853.1; -; mRNA.
DR EMBL; X74134; CAA52231.1; -; mRNA.
DR PIR; I48305; I48305.
DR RefSeq; NP_034281.2; NM_010151.3.
DR AlphaFoldDB; Q60632; -.
DR SMR; Q60632; -.
DR BioGRID; 199495; 1.
DR STRING; 10090.ENSMUSP00000089036; -.
DR iPTMnet; Q60632; -.
DR PhosphoSitePlus; Q60632; -.
DR MaxQB; Q60632; -.
DR PaxDb; Q60632; -.
DR PeptideAtlas; Q60632; -.
DR PRIDE; Q60632; -.
DR ProteomicsDB; 285253; -.
DR DNASU; 13865; -.
DR GeneID; 13865; -.
DR KEGG; mmu:13865; -.
DR CTD; 7025; -.
DR MGI; MGI:1352451; Nr2f1.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q60632; -.
DR OrthoDB; 666130at2759; -.
DR PhylomeDB; Q60632; -.
DR Reactome; R-MMU-383280; Nuclear Receptor transcription pathway.
DR BioGRID-ORCS; 13865; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Nr2f1; mouse.
DR PRO; PR:Q60632; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q60632; protein.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0021796; P:cerebral cortex regionalization; IMP:MGI.
DR GO; GO:0030900; P:forebrain development; IDA:MGI.
DR GO; GO:1904936; P:interneuron migration; IDA:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0001764; P:neuron migration; IDA:MGI.
DR GO; GO:1903800; P:positive regulation of miRNA maturation; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..422
FT /note="COUP transcription factor 1"
FT /id="PRO_0000053603"
FT DOMAIN 183..409
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 82..157
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 85..105
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 121..145
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..422
FT /note="Important for dimerization"
FT CONFLICT 36..37
FT /note="Missing (in Ref. 2; AAA19853)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="Q -> A (in Ref. 2; AAA19853)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 422 AA; 46085 MW; C16591638E1E2500 CRC64;
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQAGSGAPHT PQTPGQPGAP
ATPGTQGDKG QGPPGSGQSQ QHIECVVCGD KSSGKHYGQF TCEGCKSFFK RSVRRNLTYT
CRANRNCPID QHHRNQCQYC RLKKCLKVGM RREAVQRGRM PPTQPNPGQY ALTNGDPLNG
HCYLSGYISL LLRAEPYPTS RYGSQCMQPN NIMGIENICE LAARLLFSAV EWARNIPFFP
DLQITDQVSL LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI
FQEQVEKLKA LHVDSAEYSC LKAIVLFTSD ACGLSDAAHI ESLQEKSQCA LEEYVRSQYP
NQPSRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET LIRDMLLSGS SFNWPYMSIQ
CS
