COT2_MOUSE
ID COT2_MOUSE Reviewed; 414 AA.
AC P43135;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=COUP transcription factor 2;
DE Short=COUP-TF2;
DE AltName: Full=Apolipoprotein AI regulatory protein 1;
DE Short=ARP-1;
DE AltName: Full=COUP transcription factor II;
DE Short=COUP-TF II;
DE AltName: Full=Nuclear receptor subfamily 2 group F member 2;
GN Name=Nr2f2; Synonyms=Aporp1, Arp-1, Arp1, Tfcoup2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7947324; DOI=10.1016/0925-4773(94)90098-1;
RA Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S., Vervaart J.M.A.,
RA Schoorlemmer J., Kruijer W.;
RT "Cloning and expression during development of three murine members of the
RT COUP family of nuclear orphan receptors.";
RL Mech. Dev. 47:81-97(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=8183930; DOI=10.1073/pnas.91.10.4451;
RA Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.;
RT "Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-
RT transcription factors in the developing mouse central nervous system:
RT evidence for a role in segmental patterning of the diencephalon.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH ZFPM2, AND MUTAGENESIS OF 363-LEU--LEU-367.
RX PubMed=11382775; DOI=10.1074/jbc.m103577200;
RA Huggins G.S., Bacani C.J., Boltax J., Aikawa R., Leiden J.M.;
RT "Friend of GATA 2 physically interacts with chicken ovalbumin upstream
RT promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent
RT activation of the atrial natriuretic factor promoter.";
RL J. Biol. Chem. 276:28029-28036(2001).
CC -!- FUNCTION: Ligand-activated transcription factor. Activated by high
CC concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but
CC not by dexamethasone, cortisol or progesterone (in vitro). Regulation
CC of the apolipoprotein A-I gene transcription. Binds to DNA site A. May
CC be required to establish ovary identity during early gonad development.
CC {ECO:0000250|UniProtKB:P24468}.
CC -!- SUBUNIT: Interacts with SQSTM1. Binds DNA as a dimer; homodimer or
CC heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A
CC (By similarity). Interacts with ZFPM2. {ECO:0000250,
CC ECO:0000269|PubMed:11382775}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000305}.
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DR EMBL; X76653; CAA54096.1; -; mRNA.
DR EMBL; U07635; AAA19854.1; -; mRNA.
DR EMBL; BC042484; AAH42484.1; -; mRNA.
DR CCDS; CCDS21359.1; -.
DR RefSeq; NP_033827.2; NM_009697.3.
DR AlphaFoldDB; P43135; -.
DR SMR; P43135; -.
DR BioGRID; 198166; 1.
DR IntAct; P43135; 2.
DR MINT; P43135; -.
DR STRING; 10090.ENSMUSP00000032768; -.
DR iPTMnet; P43135; -.
DR PhosphoSitePlus; P43135; -.
DR PaxDb; P43135; -.
DR PeptideAtlas; P43135; -.
DR PRIDE; P43135; -.
DR ProteomicsDB; 283355; -.
DR Antibodypedia; 16260; 331 antibodies from 34 providers.
DR DNASU; 11819; -.
DR Ensembl; ENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551.
DR GeneID; 11819; -.
DR KEGG; mmu:11819; -.
DR UCSC; uc009hni.1; mouse.
DR CTD; 7026; -.
DR MGI; MGI:1352452; Nr2f2.
DR VEuPathDB; HostDB:ENSMUSG00000030551; -.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000157540; -.
DR InParanoid; P43135; -.
DR OMA; NWPYMST; -.
DR OrthoDB; 666130at2759; -.
DR PhylomeDB; P43135; -.
DR TreeFam; TF352097; -.
DR BioGRID-ORCS; 11819; 8 hits in 76 CRISPR screens.
DR ChiTaRS; Nr2f2; mouse.
DR PRO; PR:P43135; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P43135; protein.
DR Bgee; ENSMUSG00000030551; Expressed in gonadal ridge and 316 other tissues.
DR ExpressionAtlas; P43135; baseline and differential.
DR Genevisible; P43135; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0004879; F:nuclear receptor activity; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0001972; F:retinoic acid binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008585; P:female gonad development; ISS:UniProtKB.
DR GO; GO:0009566; P:fertilization; IMP:MGI.
DR GO; GO:0030900; P:forebrain development; IDA:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:1904936; P:interneuron migration; IDA:MGI.
DR GO; GO:0001945; P:lymph vessel development; IEP:BHF-UCL.
DR GO; GO:0060838; P:lymphatic endothelial cell fate commitment; ISO:MGI.
DR GO; GO:0001893; P:maternal placenta development; IMP:MGI.
DR GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; ISO:MGI.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; ISO:MGI.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0001764; P:neuron migration; IDA:MGI.
DR GO; GO:0060674; P:placenta blood vessel development; IMP:MGI.
DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0009956; P:radial pattern formation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
DR GO; GO:0060707; P:trophoblast giant cell differentiation; IMP:MGI.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..414
FT /note="COUP transcription factor 2"
FT /id="PRO_0000053607"
FT DOMAIN 177..403
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 76..151
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 79..99
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 115..139
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..414
FT /note="Interaction with ZFPM2"
FT /evidence="ECO:0000269|PubMed:11382775"
FT REGION 337..414
FT /note="Important for dimerization"
FT COMPBIAS 26..41
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 51
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P24468"
FT MUTAGEN 363..367
FT /note="LLLRL->RSLRF: Abolishes interaction with ZFPM2."
FT /evidence="ECO:0000269|PubMed:11382775"
FT CONFLICT 36
FT /note="A -> P (in Ref. 1; CAA54096)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 414 AA; 45571 MW; C24CB2E8C8A27E8C CRC64;
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ
GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN
CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG
YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD
QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF
GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ
