COT2_RAT
ID COT2_RAT Reviewed; 414 AA.
AC O09018;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=COUP transcription factor 2;
DE Short=COUP-TF2;
DE AltName: Full=Apolipoprotein A-I regulatory protein 1;
DE Short=ARP-1;
DE AltName: Full=COUP transcription factor II;
DE Short=COUP-TF II;
DE AltName: Full=COUPb;
DE AltName: Full=Nuclear receptor subfamily 2 group F member 2;
DE AltName: Full=Ovalbumin upstream promoter beta nuclear receptor;
GN Name=Nr2f2; Synonyms=Arp1, Tfcoup2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RA Boutin J.-M., Ronsin B., Devost D., Lipkin S.M., Rosenfeld M.G., Morel G.;
RT "Cloning and expression of COUPb and COUPg in the rat anterior pituitary.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP INTERACTION WITH SQSTM1.
RX PubMed=8910285; DOI=10.1074/jbc.271.44.27197;
RA Marcus S.L., Winrow C.J., Capone J.P., Rachubinski R.A.;
RT "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone
RT receptor.";
RL J. Biol. Chem. 271:27197-27200(1996).
CC -!- FUNCTION: Ligand-activated transcription factor. Activated by high
CC concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but
CC not by dexamethasone, cortisol or progesterone (in vitro). Regulation
CC of the apolipoprotein A-I gene transcription. Binds to DNA site A. May
CC be required to establish ovary identity during early gonad development.
CC {ECO:0000250|UniProtKB:P24468}.
CC -!- SUBUNIT: Interacts with SQSTM1. Binds DNA as a dimer; homodimer or
CC heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and
CC PPARGC1A. Interacts with ZFPM2 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000305}.
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DR EMBL; AF003944; AAB61297.1; -; mRNA.
DR RefSeq; NP_542956.1; NM_080778.2.
DR AlphaFoldDB; O09018; -.
DR SMR; O09018; -.
DR BioGRID; 250245; 1.
DR STRING; 10116.ENSRNOP00000014152; -.
DR PhosphoSitePlus; O09018; -.
DR PaxDb; O09018; -.
DR Ensembl; ENSRNOT00000014152; ENSRNOP00000014152; ENSRNOG00000010308.
DR GeneID; 113984; -.
DR KEGG; rno:113984; -.
DR UCSC; RGD:69305; rat.
DR CTD; 7026; -.
DR RGD; 69305; Nr2f2.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000157540; -.
DR InParanoid; O09018; -.
DR OMA; NWPYMST; -.
DR OrthoDB; 666130at2759; -.
DR PhylomeDB; O09018; -.
DR TreeFam; TF352097; -.
DR PRO; PR:O09018; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000010308; Expressed in stomach and 18 other tissues.
DR ExpressionAtlas; O09018; baseline and differential.
DR Genevisible; O09018; RN.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0004879; F:nuclear receptor activity; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0001972; F:retinoic acid binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0048514; P:blood vessel morphogenesis; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008585; P:female gonad development; ISS:UniProtKB.
DR GO; GO:0009566; P:fertilization; ISO:RGD.
DR GO; GO:0030900; P:forebrain development; ISO:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:1904936; P:interneuron migration; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; ISO:RGD.
DR GO; GO:0001945; P:lymph vessel development; ISO:RGD.
DR GO; GO:0060838; P:lymphatic endothelial cell fate commitment; ISO:RGD.
DR GO; GO:0001893; P:maternal placenta development; ISO:RGD.
DR GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; ISO:RGD.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; ISO:RGD.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0001764; P:neuron migration; ISO:RGD.
DR GO; GO:0060674; P:placenta blood vessel development; ISO:RGD.
DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IMP:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0009956; P:radial pattern formation; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:RGD.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0007519; P:skeletal muscle tissue development; ISO:RGD.
DR GO; GO:0060707; P:trophoblast giant cell differentiation; ISO:RGD.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..414
FT /note="COUP transcription factor 2"
FT /id="PRO_0000053608"
FT DOMAIN 177..403
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 76..151
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 79..99
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 115..139
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..414
FT /note="Interaction with ZFPM2"
FT /evidence="ECO:0000250"
FT REGION 337..414
FT /note="Important for dimerization"
FT COMPBIAS 26..41
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 51
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P24468"
SQ SEQUENCE 414 AA; 45601 MW; 5AA05165DD3F675A CRC64;
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGSQ
GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN
CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG
YISLLLRAEP YPTSRFGSQC MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD
QVALLRLTWS ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR SQYPNQPTRF
GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML LSGSSFNWPY MAIQ
