COV1_ARATH
ID COV1_ARATH Reviewed; 268 AA.
AC F4IUE7; A0A1P8AZ44; Q0WL91; Q94EH1; Q9SL69;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 04-FEB-2015, sequence version 2.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein CONTINUOUS VASCULAR RING 1 {ECO:0000303|PubMed:12668628};
GN Name=COV1 {ECO:0000303|PubMed:12668628};
GN OrderedLocusNames=At2g20120 {ECO:0000312|Araport:AT2G20120};
GN ORFNames=T2G17.8 {ECO:0000312|EMBL:AAD24385.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF PRO-76 AND GLY-130,
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=12668628; DOI=10.1242/dev.00441;
RA Parker G., Schofield R., Sundberg B., Turner S.;
RT "Isolation of COV1, a gene involved in the regulation of vascular
RT patterning in the stem of Arabidopsis.";
RL Development 130:2139-2148(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION, AND SEQUENCE REVISION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the regulation of vascular patterning in the
CC stem, probably by negatively regulating the differentiation of vascular
CC tissue. {ECO:0000269|PubMed:12668628}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers and stems, and, to a
CC lower extent, in roots and leaves. {ECO:0000269|PubMed:12668628}.
CC -!- SIMILARITY: Belongs to the plant COV1 protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF02116.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY170845; AAO41858.1; -; mRNA.
DR EMBL; AC006081; AAD24385.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06968.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61944.1; -; Genomic_DNA.
DR EMBL; AF410324; AAK95310.1; -; mRNA.
DR EMBL; AY093732; AAM10356.1; -; mRNA.
DR EMBL; AK230315; BAF02116.1; ALT_INIT; mRNA.
DR EMBL; AY084984; AAM61543.1; -; mRNA.
DR PIR; C84585; C84585.
DR RefSeq; NP_001324133.1; NM_001335662.1.
DR RefSeq; NP_565464.2; NM_127570.5.
DR AlphaFoldDB; F4IUE7; -.
DR STRING; 3702.AT2G20120.1; -.
DR PaxDb; F4IUE7; -.
DR PRIDE; F4IUE7; -.
DR ProteomicsDB; 241111; -.
DR GeneID; 816531; -.
DR KEGG; ath:AT2G20120; -.
DR Araport; AT2G20120; -.
DR TAIR; locus:2061668; AT2G20120.
DR eggNOG; ENOG502QPUG; Eukaryota.
DR HOGENOM; CLU_068050_0_1_1; -.
DR InParanoid; F4IUE7; -.
DR OrthoDB; 1076488at2759; -.
DR PhylomeDB; F4IUE7; -.
DR PRO; PR:F4IUE7; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IUE7; baseline and differential.
DR Genevisible; F4IUE7; AT.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; ISS:TAIR.
DR GO; GO:0010222; P:stem vascular tissue pattern formation; IMP:TAIR.
DR InterPro; IPR007462; COV1-like.
DR PANTHER; PTHR31876; PTHR31876; 1.
DR Pfam; PF04367; DUF502; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..268
FT /note="Protein CONTINUOUS VASCULAR RING 1"
FT /id="PRO_0000431898"
FT TOPO_DOM 1..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 71..91
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..103
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 104..124
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 21..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 76
FT /note="P->S: In cov1-1; stunted plants. Dramatic increase
FT in vascular tissue development in the stem in place of the
FT interfascicular region that normally separates the vascular
FT bundles, thus leading to an almost continuous ring of both
FT phloem and xylem tissue around the whole stem, but
FT relatively normal vascular patterning in leaves and
FT cotyledons."
FT /evidence="ECO:0000269|PubMed:12668628"
FT MUTAGEN 130
FT /note="G->R: In cov1-2; dramatic increase in vascular
FT tissue development in the stem in place of the
FT interfascicular region that normally separates the vascular
FT bundles, thus leading to an almost continuous ring of both
FT phloem and xylem tissue around the whole stem, but
FT relatively normal vascular patterning in leaves and
FT cotyledons."
FT /evidence="ECO:0000269|PubMed:12668628"
FT CONFLICT 213
FT /note="H -> R (in Ref. 4; AAK95310/AAM10356)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="I -> L (in Ref. 3; AEC06968/ANM61944)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 268 AA; 29674 MW; CAB83D38D2DABE80 CRC64;
MGDEKPVIVM ANRERDRELL IPVADSGDKD DGSSSKPSSS SSASSSSHQS SHETLSLFIR
GWASKKFMTG CVILLPIAIT FYITWWFIHF VDGFFSPIYA QLGINVFGFG FLTSIAFIFL
VGVFMSSWLG ASVLNLGEWF IKRMPFVRHI YNASKQISTA ISPDQNTQAF KEVAIIRHPR
VGEYAFGFIT STVVLQNYPT EEELCCVYVP TNHLYIGDIL LVNSNDVIRP NLSVREGIEI
VVSGGMSMPQ ILSTVDKPLA SIDRATSL
