COW1_CONTE
ID COW1_CONTE Reviewed; 63 AA.
AC Q9NDA7;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Contryphan-Tx;
DE Flags: Precursor;
OS Conus textile (Cloth-of-gold cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX NCBI_TaxID=6494;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 55-62, MASS SPECTROMETRY, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Venom, and Venom duct;
RX PubMed=11137539; DOI=10.1016/s0041-0101(00)00210-5;
RA Jimenez E.C., Watkins M., Juszczak L.J., Cruz L.J., Olivera B.M.;
RT "Contryphans from Conus textile venom ducts.";
RL Toxicon 39:803-808(2001).
CC -!- FUNCTION: Its target is unknown, but this toxin may modulate voltage-
CC activated calcium channels (Cav) or calcium-dependent potassium
CC channels (KCa). {ECO:0000250|UniProtKB:P0C248,
CC ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903,
CC ECO:0000250|UniProtKB:P83047}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11137539}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:11137539}.
CC -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=966.5; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11137539};
CC -!- MISCELLANEOUS: Exists in two forms, due to cis-trans isomerization at
CC 56-Cys-hydroxyPro-57. The cis conformation is the major form.
CC {ECO:0000250|UniProtKB:P58787}.
CC -!- SIMILARITY: Belongs to the O2 superfamily. Contryphan family.
CC {ECO:0000305}.
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DR EMBL; AF166323; AAF82243.1; -; mRNA.
DR AlphaFoldDB; Q9NDA7; -.
DR SMR; Q9NDA7; -.
DR ConoServer; 1316; Contryphan-Tx precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR InterPro; IPR011062; Contryphan_CS.
DR Pfam; PF02950; Conotoxin; 1.
DR PROSITE; PS60027; CONTRYPHAN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; D-amino acid; Hydroxylation;
KW Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..54
FT /evidence="ECO:0000305"
FT /id="PRO_0000035075"
FT PEPTIDE 55..62
FT /note="Contryphan-Tx"
FT /evidence="ECO:0000269|PubMed:11137539"
FT /id="PRO_0000035076"
FT MOD_RES 57
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P58786"
FT MOD_RES 58
FT /note="D-tryptophan"
FT /evidence="ECO:0000250|UniProtKB:P58786"
FT MOD_RES 62
FT /note="Cysteine amide"
FT /evidence="ECO:0000250|UniProtKB:P58786"
SQ SEQUENCE 63 AA; 6801 MW; DA25657C06A05EED CRC64;
MGKLTILVLV AVALLSTQVM VQGDGDQPAD RDAVPRDDNP GGMSEKFLNA LQRRGCPWQP
YCG
