ID   COW2_CONIN              Reviewed;           9 AA.
AC   P0DUQ9;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   23-FEB-2022, entry version 2.
DE   RecName: Full=Contryphan-In1172 {ECO:0000303|PubMed:33732044};
OS   Conus inscriptus (Engraved cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=257329;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AMIDATION AT ASN-9, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=33732044; DOI=10.1016/j.sjbs.2020.12.032;
RA   Jain R.P., Jayaseelan B.F., Wilson Alphonse C.R., Mahmoud A.H.,
RA   Mohammed O.B., Ahmed Almunqedhi B.M., Rajaian Pushpabai R.;
RT   "Mass spectrometric identification and denovo sequencing of novel
RT   conotoxins from vermivorous cone snail (Conus inscriptus), and preliminary
RT   screening of its venom for biological activities in vitro and in vivo.";
RL   Saudi J. Biol. Sci. 28:1582-1595(2021).
CC   -!- FUNCTION: Its target is unknown, but this toxin may modulate voltage-
CC       activated calcium channels (Cav) or calcium-dependent potassium
CC       channels (KCa). {ECO:0000250|UniProtKB:P0C248,
CC       ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903,
CC       ECO:0000250|UniProtKB:P83047}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33732044}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:33732044}.
CC   -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1172.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:33732044};
CC   -!- SIMILARITY: Belongs to the O2 superfamily. Contryphan family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..9
FT                   /note="Contryphan-In1172"
FT                   /evidence="ECO:0000269|PubMed:33732044"
FT                   /id="PRO_0000453221"
FT   MOD_RES         9
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:33732044"
FT   DISULFID        2..8
FT                   /evidence="ECO:0000250|UniProtKB:P0C249"
SQ   SEQUENCE   9 AA;  1176 MW;  8CD4A3676AB3676E CRC64;
     RCPWDPWCN