COW2_CONLI
ID COW2_CONLI Reviewed; 61 AA.
AC A0A1P8NVR4;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 1.
DT 25-MAY-2022, entry version 12.
DE RecName: Full=Contryphan-Li2 {ECO:0000305};
DE Flags: Precursor;
OS Conus lividus (Livid cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX NCBI_TaxID=89426;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=28152596; DOI=10.1021/acs.jproteome.6b00776;
RA Vijayasarathy M., Basheer S.M., Franklin J.B., Balaram P.;
RT "Contryphan genes and mature peptides in the venom of nine cone snail
RT species by transcriptomic and mass spectrometric analysis.";
RL J. Proteome Res. 16:763-772(2017).
CC -!- FUNCTION: Its target is unknown, but this toxin may modulate voltage-
CC activated calcium channels (Cav) or calcium-dependent potassium
CC channels (KCa). {ECO:0000250|UniProtKB:P0C248,
CC ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903,
CC ECO:0000250|UniProtKB:P83047}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:28152596}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:28152596}.
CC -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the O2 superfamily. Contryphan family.
CC {ECO:0000305}.
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DR EMBL; KX289880; APX52857.1; -; mRNA.
DR AlphaFoldDB; A0A1P8NVR4; -.
DR ConoServer; 9759; Contryphan-Li2 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 3: Inferred from homology;
KW Amidation; D-amino acid; Disulfide bond; Hydroxylation;
KW Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..52
FT /evidence="ECO:0000305"
FT /id="PRO_0000445132"
FT PEPTIDE 53..60
FT /note="Contryphan-Li2"
FT /evidence="ECO:0000305"
FT /id="PRO_5013247318"
FT MOD_RES 58
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:P58786"
FT MOD_RES 59
FT /note="D-tryptophan"
FT /evidence="ECO:0000250|UniProtKB:P58786"
FT MOD_RES 60
FT /note="Cysteine amide"
FT /evidence="ECO:0000250|UniProtKB:P58786"
FT DISULFID 54..60
FT /evidence="ECO:0000250|UniProtKB:P58786"
SQ SEQUENCE 61 AA; 6575 MW; 9DD949AB0480ECED CRC64;
MEKLTMLVLV AAVLLSAQVM VQGDGDQPAD RDAVPRDDNP GGTIGKFMYI LHGCPFQPWC
G