ID   COW34_CONLI             Reviewed;           7 AA.
AC   P0DUC8;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   02-DEC-2020, sequence version 1.
DT   23-FEB-2022, entry version 3.
DE   RecName: Full=Contryphan Li834 {ECO:0000303|PubMed:28400262};
OS   Conus lividus (Livid cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=89426;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND DISULFIDE
RP   BOND.
RC   TISSUE=Venom;
RX   PubMed=28400262; DOI=10.1016/j.toxicon.2017.04.003;
RA   Franklin J.B., Rajesh R.P., Vinithkumar N.V., Kirubagaran R.;
RT   "Identification of short single disulfide-containing contryphans from the
RT   venom of cone snails using de novo mass spectrometry-based sequencing
RT   methods.";
RL   Toxicon 132:50-54(2017).
CC   -!- FUNCTION: Its target is unknown, but this toxin may modulate voltage-
CC       activated calcium channels (Cav) or calcium-dependent potassium
CC       channels (KCa). {ECO:0000250|UniProtKB:P0C248,
CC       ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903,
CC       ECO:0000250|UniProtKB:P83047}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28400262}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:28400262}.
CC   -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=835.0; Method=Electrospray; Note=Average mass.;
CC       Evidence={ECO:0000269|PubMed:28400262};
CC   -!- SIMILARITY: Belongs to the O2 superfamily. Contryphan family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..7
FT                   /note="Contryphan Li834"
FT                   /evidence="ECO:0000269|PubMed:28400262"
FT                   /id="PRO_0000451482"
FT   DISULFID        1..7
FT                   /evidence="ECO:0000269|PubMed:28400262"
SQ   SEQUENCE   7 AA;  837 MW;  6EA2D777741B5ED0 CRC64;
     CYRPPVC