COW_CONLE
ID COW_CONLE Reviewed; 9 AA.
AC P0DUC3;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 02-DEC-2020, sequence version 1.
DT 23-FEB-2022, entry version 3.
DE RecName: Full=Contryphan Le925 {ECO:0000303|PubMed:28400262};
DE Contains:
DE RecName: Full=Contryphan Le851 {ECO:0000303|PubMed:28400262};
DE Contains:
DE RecName: Full=Contryphan Le755 {ECO:0000303|PubMed:28400262};
DE Contains:
DE RecName: Full=Contryphan Le685 {ECO:0000303|PubMed:28400262};
OS Conus leopardus (Leopard cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX NCBI_TaxID=101306;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AMIDATION AT
RP PRO-8, HYDROXYLATION AT PRO-8, AND DISULFIDE BOND.
RC TISSUE=Venom;
RX PubMed=28400262; DOI=10.1016/j.toxicon.2017.04.003;
RA Franklin J.B., Rajesh R.P., Vinithkumar N.V., Kirubagaran R.;
RT "Identification of short single disulfide-containing contryphans from the
RT venom of cone snails using de novo mass spectrometry-based sequencing
RT methods.";
RL Toxicon 132:50-54(2017).
CC -!- FUNCTION: Its target is unknown, but this toxin may modulate voltage-
CC activated calcium channels (Cav) or calcium-dependent potassium
CC channels (KCa). {ECO:0000250|UniProtKB:P0C248,
CC ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903,
CC ECO:0000250|UniProtKB:P83047}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28400262}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:28400262}.
CC -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: [Contryphan Le925]: Mass=926.0; Method=Electrospray;
CC Note=Average mass.; Evidence={ECO:0000269|PubMed:28400262};
CC -!- MASS SPECTROMETRY: [Contryphan Le851]: Mass=851.9; Method=Electrospray;
CC Note=Average mass.; Evidence={ECO:0000269|PubMed:28400262};
CC -!- MASS SPECTROMETRY: [Contryphan Le755]: Mass=755.8; Method=Electrospray;
CC Note=Average mass.; Evidence={ECO:0000269|PubMed:28400262};
CC -!- MASS SPECTROMETRY: [Contryphan Le685]: Mass=684.7; Method=Electrospray;
CC Note=Average mass.; Evidence={ECO:0000269|PubMed:28400262};
CC -!- SIMILARITY: Belongs to the O2 superfamily. Contryphan family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond; Hydroxylation;
KW Ion channel impairing toxin; Secreted; Toxin.
FT PEPTIDE 1..9
FT /note="Contryphan Le925"
FT /evidence="ECO:0000269|PubMed:28400262"
FT /id="PRO_0000451474"
FT PEPTIDE 1..8
FT /note="Contryphan Le851"
FT /evidence="ECO:0000269|PubMed:28400262"
FT /id="PRO_0000451475"
FT PEPTIDE 1..7
FT /note="Contryphan Le755"
FT /evidence="ECO:0000269|PubMed:28400262"
FT /id="PRO_0000451476"
FT PEPTIDE 1..6
FT /note="Contryphan Le685"
FT /evidence="ECO:0000269|PubMed:28400262"
FT /id="PRO_0000451477"
FT MOD_RES 8
FT /note="4-hydroxyproline; in Contryphan Le925"
FT /evidence="ECO:0000269|PubMed:28400262"
FT MOD_RES 8
FT /note="Proline amide; in Contryphan Le851"
FT /evidence="ECO:0000269|PubMed:28400262"
FT DISULFID 1..6
FT /evidence="ECO:0000269|PubMed:28400262"
FT UNSURE 3
FT /note="I or L"
FT /evidence="ECO:0000269|PubMed:28400262"
SQ SEQUENCE 9 AA; 912 MW; D4E86DDEBAB5B059 CRC64;
CFISDCAPG
