COX10_ARATH
ID COX10_ARATH Reviewed; 431 AA.
AC O64886; Q94AL4;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 4.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Protoheme IX farnesyltransferase, mitochondrial;
DE EC=2.5.1.141 {ECO:0000250|UniProtKB:P24009};
DE AltName: Full=Cytochrome c oxidase assembly protein COX10;
DE AltName: Full=Heme O synthase;
DE Flags: Precursor;
GN Name=COX10; OrderedLocusNames=At2g44520; ORFNames=F16B22_1, F4I1.50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Converts protoheme IX and farnesyl diphosphate to heme O.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate +
CC Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530,
CC ChEBI:CHEBI:175763; EC=2.5.1.141;
CC Evidence={ECO:0000250|UniProtKB:P24009};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ubiA prenyltransferase (TC 3.D.4.8) family.
CC {ECO:0000305}.
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DR EMBL; AC003672; AAC27454.3; -; Genomic_DNA.
DR EMBL; AC004521; AAM14960.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10432.1; -; Genomic_DNA.
DR EMBL; AY045952; AAK76626.1; -; mRNA.
DR EMBL; AY114016; AAM45064.1; -; mRNA.
DR PIR; E84879; E84879.
DR PIR; T01579; T01579.
DR RefSeq; NP_566019.1; NM_130015.4.
DR AlphaFoldDB; O64886; -.
DR SMR; O64886; -.
DR STRING; 3702.AT2G44520.1; -.
DR PaxDb; O64886; -.
DR PRIDE; O64886; -.
DR EnsemblPlants; AT2G44520.1; AT2G44520.1; AT2G44520.
DR GeneID; 819059; -.
DR Gramene; AT2G44520.1; AT2G44520.1; AT2G44520.
DR KEGG; ath:AT2G44520; -.
DR Araport; AT2G44520; -.
DR TAIR; locus:2042316; AT2G44520.
DR eggNOG; KOG1380; Eukaryota.
DR HOGENOM; CLU_029631_1_0_1; -.
DR InParanoid; O64886; -.
DR OMA; MYLKRAT; -.
DR OrthoDB; 1260807at2759; -.
DR PhylomeDB; O64886; -.
DR PRO; PR:O64886; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O64886; baseline and differential.
DR Genevisible; O64886; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004311; F:farnesyltranstransferase activity; IBA:GO_Central.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006783; P:heme biosynthetic process; IBA:GO_Central.
DR CDD; cd13957; PT_UbiA_Cox10; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR HAMAP; MF_00154; CyoE_CtaB; 1.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR016315; Protohaem_IX_farnesylTrfase_mt.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR044878; UbiA_sf.
DR PANTHER; PTHR43448; PTHR43448; 1.
DR Pfam; PF01040; UbiA; 1.
DR PIRSF; PIRSF001773; COX10; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
PE 2: Evidence at transcript level;
KW Heme biosynthesis; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transferase; Transit peptide; Transmembrane;
KW Transmembrane helix.
FT TRANSIT 1..33
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 34..431
FT /note="Protoheme IX farnesyltransferase, mitochondrial"
FT /id="PRO_0000412563"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 431 AA; 46475 MW; ECBEB38647DA9A30 CRC64;
MWRRSVVYRF SSRISVSSSL PNPRLIPWSR ELCAVNSFSQ PPVSTESTAK LGITGVRSDA
NRVFATATAA ATATATTGEI SSRVAALAGL GHHYARCYWE LSKAKLSMLV VATSGTGYIL
GTGNAAISFP GLCYTCAGTM MIAASANSLN QIFEISNDSK MKRTMLRPLP SGRISVPHAV
AWATIAGASG ACLLASKTNM LAAGLASANL VLYAFVYTPL KQLHPINTWV GAVVGAIPPL
LGWAAASGQI SYNSMILPAA LYFWQIPHFM ALAHLCRNDY AAGGYKMLSL FDPSGKRIAA
VALRNCFYMI PLGFIAYDWG LTSSWFCLES TLLTLAIAAT AFSFYRDRTM HKARKMFHAS
LLFLPVFMSG LLLHRVSNDN QQQLVEEAGL TNSVSGEVKT QRRKKRVAQP PVAYASAAPF
PFLPAPSFYS P
