ID   COX10_CANGA             Reviewed;         451 AA.
AC   Q6FUG4;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Protoheme IX farnesyltransferase, mitochondrial;
DE            EC=2.5.1.-;
DE   AltName: Full=Heme O synthase;
DE   Flags: Precursor;
GN   Name=COX10; OrderedLocusNames=CAGL0F03685g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Converts protoheme IX and farnesyl diphosphate to heme O.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; CR380952; CAG59054.1; -; Genomic_DNA.
DR   RefSeq; XP_446130.1; XM_446130.1.
DR   AlphaFoldDB; Q6FUG4; -.
DR   SMR; Q6FUG4; -.
DR   STRING; 5478.XP_446130.1; -.
DR   EnsemblFungi; CAG59054; CAG59054; CAGL0F03685g.
DR   GeneID; 2887706; -.
DR   KEGG; cgr:CAGL0F03685g; -.
DR   CGD; CAL0130930; CAGL0F03685g.
DR   VEuPathDB; FungiDB:CAGL0F03685g; -.
DR   eggNOG; KOG1380; Eukaryota.
DR   HOGENOM; CLU_029631_2_1_1; -.
DR   InParanoid; Q6FUG4; -.
DR   OMA; MGREPDF; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:InterPro.
DR   GO; GO:0006784; P:heme A biosynthetic process; IEA:EnsemblFungi.
DR   CDD; cd13957; PT_UbiA_Cox10; 1.
DR   Gene3D; 1.10.357.140; -; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR016315; Protohaem_IX_farnesylTrfase_mt.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   InterPro; IPR044878; UbiA_sf.
DR   PANTHER; PTHR43448; PTHR43448; 1.
DR   Pfam; PF01040; UbiA; 1.
DR   PIRSF; PIRSF001773; COX10; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis; Membrane; Mitochondrion; Reference proteome;
KW   Transferase; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..451
FT                   /note="Protoheme IX farnesyltransferase, mitochondrial"
FT                   /id="PRO_0000045413"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   451 AA;  50558 MW;  CBDE43F94C32F1AB CRC64;
     MLVRTLYISS SVGSSNMLCN HGLKVIGKYS AIHEATRKII VRSYSKETIK KHNKQAILNT
     APIEFIANNS PLVGISDVNT IKEAAKRTLR CTDDVTDDQT DEIHPHLPFN VKPVDGKARA
     ALKKEKNSMS LDIKKTMEAY VQLTKPRLTI LVMLSAICSY ALSPYPATVT ELLCLTVGTT
     MCSGAANAIN MGREPDYDRQ MIRTQARPVV RGAVTPKQAF SFAFGMGTLG TSILYLGVNP
     TVAALGLSNI ALYSWIYTSL KRKHIINTWV GALVGAIPPL MGWAAASPLT HPGSWCLAGL
     LYAWQFPHFN TLSHNIRNEY KNAGYVMTAW KNPLLNARVA LRYSLLMFPL CFGLSYFNIT
     DWYYQIDSGL VNAWLCLWSF KFYMQQRLNY SSKIKNDRVK FNEGLATANV YARKAFFASV
     LHLPAVLILA ILHKKNRWDW LFEDSENPKL K