COX10_MOUSE
ID COX10_MOUSE Reviewed; 443 AA.
AC Q8CFY5;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protoheme IX farnesyltransferase, mitochondrial;
DE EC=2.5.1.141 {ECO:0000250|UniProtKB:P24009};
DE AltName: Full=Heme O synthase;
DE Flags: Precursor;
GN Name=Cox10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Converts protoheme IX and farnesyl diphosphate to heme O.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate +
CC Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530,
CC ChEBI:CHEBI:175763; EC=2.5.1.141;
CC Evidence={ECO:0000250|UniProtKB:P24009};
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC {ECO:0000305}.
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DR EMBL; AL603889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL663033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038046; AAH38046.1; -; mRNA.
DR CCDS; CCDS24839.1; -.
DR RefSeq; NP_848466.1; NM_178379.3.
DR AlphaFoldDB; Q8CFY5; -.
DR SMR; Q8CFY5; -.
DR STRING; 10090.ENSMUSP00000040138; -.
DR PhosphoSitePlus; Q8CFY5; -.
DR EPD; Q8CFY5; -.
DR MaxQB; Q8CFY5; -.
DR PaxDb; Q8CFY5; -.
DR PRIDE; Q8CFY5; -.
DR ProteomicsDB; 284100; -.
DR Antibodypedia; 25099; 228 antibodies from 25 providers.
DR DNASU; 70383; -.
DR Ensembl; ENSMUST00000049091; ENSMUSP00000040138; ENSMUSG00000042148.
DR GeneID; 70383; -.
DR KEGG; mmu:70383; -.
DR UCSC; uc007jko.2; mouse.
DR CTD; 1352; -.
DR MGI; MGI:1917633; Cox10.
DR VEuPathDB; HostDB:ENSMUSG00000042148; -.
DR eggNOG; KOG1380; Eukaryota.
DR GeneTree; ENSGT00940000153771; -.
DR HOGENOM; CLU_029631_2_2_1; -.
DR InParanoid; Q8CFY5; -.
DR OMA; MQLNRNL; -.
DR OrthoDB; 1260807at2759; -.
DR PhylomeDB; Q8CFY5; -.
DR TreeFam; TF105071; -.
DR Reactome; R-MMU-189451; Heme biosynthesis.
DR BioGRID-ORCS; 70383; 18 hits in 76 CRISPR screens.
DR ChiTaRS; Cox10; mouse.
DR PRO; PR:Q8CFY5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8CFY5; protein.
DR Bgee; ENSMUSG00000042148; Expressed in animal zygote and 219 other tissues.
DR ExpressionAtlas; Q8CFY5; baseline and differential.
DR Genevisible; Q8CFY5; MM.
DR GO; GO:0070069; C:cytochrome complex; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0004311; F:farnesyltranstransferase activity; ISO:MGI.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009060; P:aerobic respiration; IMP:MGI.
DR GO; GO:0017004; P:cytochrome complex assembly; IDA:MGI.
DR GO; GO:0006784; P:heme A biosynthetic process; IDA:MGI.
DR GO; GO:0006783; P:heme biosynthetic process; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0000266; P:mitochondrial fission; IMP:MGI.
DR GO; GO:0007005; P:mitochondrion organization; IMP:MGI.
DR GO; GO:0018343; P:protein farnesylation; ISO:MGI.
DR GO; GO:0008535; P:respiratory chain complex IV assembly; ISO:MGI.
DR CDD; cd13957; PT_UbiA_Cox10; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR HAMAP; MF_00154; CyoE_CtaB; 1.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR016315; Protohaem_IX_farnesylTrfase_mt.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR InterPro; IPR044878; UbiA_sf.
DR PANTHER; PTHR43448; PTHR43448; 1.
DR Pfam; PF01040; UbiA; 1.
DR PIRSF; PIRSF001773; COX10; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR PROSITE; PS00943; UBIA; 1.
PE 2: Evidence at transcript level;
KW Heme biosynthesis; Lipid metabolism; Membrane; Mitochondrion;
KW Reference proteome; Transferase; Transit peptide; Transmembrane;
KW Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..443
FT /note="Protoheme IX farnesyltransferase, mitochondrial"
FT /id="PRO_0000035924"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 68..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 48884 MW; 11DDF4F70FD31F61 CRC64;
MAASPHTISS RLLTGSVGGC IWYLERRAIQ GLPHRVTRLF RNVSNQWVTL QHLSFLKRMY
VTQLHRGLSQ RVKPKPEPPA SPFLEHTSSG QARADEDELP SFPAPSRPLS RKPNEELVEL
EATSIVDHSL DTAKEKKEER QWKEMKLHTD DLPGILARLS KIKLTALVVS TTSAGFALAP
GPFDWSCFLL TSLGTGLASC AANSINQFFE VPFDSNMNRT KNRPLVRGQI SPLLAVSFAT
CCAVPGVALL TWGVNPLTGA LGVFNIFLYT CCYTPLKRVS ITNTWVGAVV GAIPPVMGWT
AATGSLDAGA LLLGGILYSW QFPHFNALSW GLREDYSRGG YCMMSVTHPA LCRRVALRHC
LALIALSTAA PVLDITTWVF PVISLPINLY ISYLGFRFYV DADRRSSRKL FFCSLWHLPL
LLLLMLTCKQ RPGQEGDKGE APS
